Ribosome inactivating protein: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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 <StructureSection load='' size='350' side='right' caption='Ribosome inactivating protein from pokeweed complex with adenine (PDB code [[1qci]])' scene='70/706276/Cv/1'>
 == Function ==
-'''Ribosome inactivating protein''' (RIP) is a bacterial or plant toxin which inhibits protein synthesis.  RIP inactivates the ribosomal 60S subunit by N-glycosidic cleavage which results in releasing a specific adenine from 28S rRNA<ref>PMID:3510899</ref>.  '''Type 1 RIP''' have a single chain, while '''type 2 RIP''' (i.e., ricin, ebulin and nigrin) have two chains.  '''Momorcharin''' is a RIP isolated from several plants<ref>PMID:23777339</ref>.
+'''Ribosome inactivating protein''' (RIP) is a bacterial or plant toxin which inhibits protein synthesis.  RIP inactivates the ribosomal 60S subunit by N-glycosidic cleavage which results in releasing a specific adenine from 28S rRNA<ref>PMID:3510899</ref>.  '''Type 1 RIP''' have a single chain, while '''type 2 RIP''' (i.e., ricin, ebulin and nigrin) have two chains.  '''Momorcharin''' is a RIP isolated from several plants<ref>PMID:23777339</ref>. '''Trichosanthin''' is a RIP isolated from snake gourd<ref>PMID:15804517</ref>.
 == Relevance ==
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 [[Ribosome inactivating protein 3D structures]]
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-{{#tree:id=OrganizedByTopic|openlevels=0|
-*Pokeweed ribosome inactivating protein
-**[[1apa]], [[1paf]], [[1pag]], [[1qcg]] – apRIP – american pokeweed <br />
-**[[1j1q]], [[1gik]] – apRIP-S<br />
-**[[1j1r]] – apRIP-S + adenine<br />
-**[[1j1s]] – apRIP-S + formycin<br />
-**[[1qci]] – apRIP + adenine<br />
-**[[1d6a]] – apRIP + guanine<br />
-**[[1qcj]] – apRIP + pteoric acid<br />
-**[[1lln]] – apRIP-3 + methylated lysine<br />
-*Phytolacca dioica ribosome inactivating protein
-**[[3h5k]] – PdRIP PD-L1 – ''Phytolacca dioica''<br />
-**[[3le7]] – PdRIP PD-L1 + adenine <br />
-**[[2z4u]] – PdRIP PD-L4 <br />
-**[[2z53]] – PdRIP PD-L4 (mutant) <br />
-**[[2qes]] – PdRIP PD-L4 + adenine <br />
-**[[2qet]] – PdRIP PD-L4 (mutant) + adenine<br />
-*Dianthin 30 ribosome inactivating protein
-**[[1lp8]], [[1rl0]] – cpRIP – clove pink<br />
-**[[1lpc]] – cpRIP + cAMP<br />
-**[[1lpd]] – cpRIP + adenine<br />
-*Type 1 ribosome inactivating protein
-**[[2g5x]] – RIP – scarlet lychnis<br />
-**[[3ctk]] – RIP – bougainvillea<br />
-**[[3mrw]], [[3s9q]], [[4kmk]], [[4kwn]], [[4l66]], [[1cf5]], [[5gm7]], [[4rzj]] – bgRIP – bitter gourd<br />
-**[[1f8q]], [[1aha]], [[1ahb]], [[1ahc]], [[1mri]] – bpα-RIP – balsam pear <br />
-**[[3mvg]] – RIP – dutch iris <br />
-**[[6z1y]] – sgRIP trichosanthin – snake gourd <br />
-**[[6yts]] – sgRIP trichosanthin - NMR<br />
-*Type 1 ribosome inactivating protein complex with nucleotide
-**[[3mry]] – bgRIP + aminopurine<br />
-**[[4kpv]], [[5y48]] – bgRIP + pyrimidine derivative<br />
-**[[3rl9]], [[3u6z]], [[3u70]], [[3v2k]] – bgRIP + adenine<br />
-**[[4dwm]], [[4rzj]] – bgRIP + NAG<br />
-**[[3n1n]], [[3my6]] – baRIP + guanine – balsam apple <br />
-**[[4f9n]], [[4i47]] – bgRIP + guanine<br />
-**[[5ilx]], [[4o0o]] – bgRIP + uracil derivative<br />
-**[[5cso]], [[5cst]] – bgRIP + cytidine<br />
-**[[4zt8]] – bgRIP + cytosine<br />
-**[[4zu0]], [[4zz6]], [[4z44]], [[4o4q]], [[4o8e]], [[4q9f]], [[1mrg]], [[3q4p]], [[3qji]], [[4emf]], [[4emr]], [[5cso]], [[5cst]], [[5ilw]], [[5ilx]] – bgα-RIP + nucleotide <br />
-*Type 1 ribosome inactivating protein complex with peptide
-**[[4fxa]], [[4lt4]], [[4m5a]] – bgRIP + arginine derivative<br />
-**[[3n3x]] – baRIP + polypeptide <br />
-**[[3n2d]] – bgRIP + polypeptide <br />
-*Type 1 ribosome inactivating protein other complexes
-**[[3n31]], [[3n5d]], [[3n31]], [[3nfm]], [[3njs]], [[3nx9]], [[3n1d]] – baRIP + sugar <br />
-**[[3v14]], [[4fz9]], [[4guw]], [[4hoa]], [[5wv1]] – bgRIP + sugar <br />
-**[[4lro]] – bgRIP + spermidine<br />
-**[[5y48]] – bgRIP + pyrimidine derivative<br />
-**[[3sj6]] – bgRIP + oxalane derivative<br />
-**[[3u6t]] – bgRIP + kanamycin<br />
-**[[3u8f]] – bgRIP + mycolic acid<br />
-**[[4h0z]] – bgRIP + acetyl-muramic acid<br />
-**[[4jtp]] – bgRIP + ascorbic acid<br />
-**[[4k2z]] – bgRIP + methylethylamine<br />
-**[[5cix]] – bgRIP + triethanolamine<br />
-**[[5gz7]] – bgRIP + PEG<br />
-**[[4k2z]] – bgRIP + ethanediol<br />
-**[[4jtb]] – bgRIP + phosphate<br />
-**[[4lwx]] – bgRIP + peptidoglycan<br />
-**[[4yp2]] – bgRIP + nicotinamide<br />
-**[[1mrh]] – bpα-RIP + formycin<br />
-**[[4fz9]], [[4xy7]] – bgα-RIP + disaccharide <br />
-**[[5cf9]] – bgα-RIP + NADP <br />
-*Type 2 ribosome inactivating protein
-**[[5y42]] – sgRIP <br />
-**[[2jjr]], [[2vs6]] – sgRIP trichosanthin (mutant) <br />
-**[[2mll]] – RIP – mistletoe<br />
-**[[2vlc]] – RIP cinnamomin – camphor tree<br />
-*Ribosome inactivating protein
-**[[2k6h]] – cRIP – corn - NMR<br />
-**[[2pqg]], [[2pqi]] – cRIP3 <br />
-**[[2pqj]] – cRIP3 + adenine<br />
-**[[2oqa]] – spgRIP – sponge gourd <br />
-**[[2l37]], [[6o3s]] – spgRIP - NMR<br />
-**[[3ktz]] – GmRIP gelonin – ''Gelonium multiforum''<br />
-**[[3ku0]] – GmRIP gelonin + adenine<br />
-*Momorcharin or momordin
-**[[1f8q]], [[1aha]], [[1ahb]], [[1ahc]], [[1mri]] – bpa-RIP – balsam pear <br />
-**[[1mrg]] – bpa-RIP + adenosine <br />
-**[[1mrh]] – bpa-RIP + formycin<br />
-**[[1cf5]] – bpb-RIP  <br />
-**[[6loq]], [[6lor]],  [[6lov]], [[6low]], [[6loy]], [[6loz]], [[6lp0]] – bg-RIP + nucleotide – bitter gourd <br />
-}}
 == References ==
 <references/>
 [[Category:Topic Page]]