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| <StructureSection load='1qci' size='350' side='right' caption='Ribosome inactivating protein from pokeweed complex with adenine (PDB code [[1qci]])' scene='70/706276/Cv/1'> | | <StructureSection load='' size='350' side='right' caption='Ribosome inactivating protein from pokeweed complex with adenine (PDB code [[1qci]])' scene='70/706276/Cv/1'> |
| == Function == | | == Function == |
| '''Ribosome inactivating protein''' (RIP) is a bacterial or plant toxin which inhibits protein synthesis. RIP inactivates the ribosomal 60S subunit by N-glycosidic cleavage which results in releasing a specific adenine from 28S rRNA<ref>PMID:3510899</ref>. '''Type 1 RIP''' have a single chain, while '''type 2 RIP''' (i.e., ricin, ebulin and nigrin) have two chains. '''Momorcharin''' is a RIP isolated from several plants<ref>PMID:23777339</ref>. | | '''Ribosome inactivating protein''' (RIP) is a bacterial or plant toxin which inhibits protein synthesis. RIP inactivates the ribosomal 60S subunit by N-glycosidic cleavage which results in releasing a specific adenine from 28S rRNA<ref>PMID:3510899</ref>. '''Type 1 RIP''' have a single chain, while '''type 2 RIP''' (i.e., ricin, ebulin and nigrin) have two chains. '''Momorcharin''' is a RIP isolated from several plants<ref>PMID:23777339</ref>. '''Trichosanthin''' is a RIP isolated from snake gourd<ref>PMID:15804517</ref>. |
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| == Relevance == | | == Relevance == |
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| == Structural highlights == | | == Structural highlights == |
| The <scene name='70/706276/Cv/2'>active site of pokeweed RIP contains adenine</scene><ref>PMID:10493577</ref>. Water molecules shown as red spheres. | | The <scene name='70/706276/Cv/3'>active site of pokeweed RIP contains adenine</scene><ref>PMID:10493577</ref>. Water molecules are shown as red spheres. |
| </StructureSection> | | </StructureSection> |
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| == 3D Structures of ribosome inactivating protein == | | == 3D Structures of ribosome inactivating protein == |
| | [[Ribosome inactivating protein 3D structures]] |
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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| {{#tree:id=OrganizedByTopic|openlevels=0|
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| *Pokeweed ribosome inactivating protein
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| **[[1apa]], [[1paf]], [[1pag]], [[1qcg]] – apRIP – american pokeweed <br />
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| **[[1j1q]], [[1gik]] – apRIP-S<br />
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| **[[1j1r]] – apRIP-S + adenine<br />
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| **[[1j1s]] – apRIP-S + formycin<br />
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| **[[1qci]] – apRIP + adenine<br />
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| **[[1d6a]] – apRIP + guanine<br />
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| **[[1qcj]] – apRIP + pteoric acid<br />
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| **[[1lln]] – apRIP-3 + methylated lysine<br />
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| *Dianthin 30 ribosome inactivating protein
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| **[[1lp8]], [[1rl0]] – cpRIP – clove pink<br />
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| **[[1lpc]] – cpRIP + cAMP<br />
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| **[[1lpd]] – cpRIP + adenine<br />
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| *Type 1 ribosome inactivating protein
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| **[[2g5x]] – RIP – scarlet lychnis<br />
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| **[[3ctk]] – RIP – bougainvillea<br />
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| **[[3mrw]], [[3s9q]], [[4kmk]], [[4kwn]], [[4l66]] – bgRIP – bitter gourd<br />
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| *Type 1 ribosome inactivating protein complex with nucleotide
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| **[[3mry]] – bgRIP + aminopurine<br />
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| **[[4kpv]] – bgRIP + pyrimidine derivative<br />
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| **[[3rl9]], [[3u6z]], [[3u70]], [[3v2k]] – bgRIP + adenine<br />
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| **[[4dwm]], [[4rzj]] – bgRIP + NAG<br />
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| **[[3n1n]], [[3my6]] – baRIP + guanine – balsam apple <br />
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| **[[4f9n]], [[4i47]] – bgRIP + guanine<br />
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| **[[4fpz]], [[4o0o]] – bgRIP + uracil derivative<br />
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| **[[4g2x]], [[4k6p]], [[4ztw]] – bgRIP + cytidine<br />
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| **[[4kjh]], [[4zt8]] – bgRIP + cytosine<br />
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| **[[4k6q]], [[4zu0]] – bgRIP + CMP<br />
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| **[[4qgj]], [[4z44]] – bgRIP + CDP<br />
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| **[[4k6s]], [[4zz6]] – bgRIP + CTP<br />
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| **[[4o4q]] – bgRIP + UDP<br />
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| **[[4o8e]] – bgRIP + UTP<br />
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| **[[4q9f]] – bgRIP + GMP<br />
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| **[[3q4p]], [[3qji]], [[4emf]], [[4emr]] – bgRIP + guanosine derivative<br />
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| *Type 1 ribosome inactivating protein complex with peptide
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| **[[4fxa]], [[4lt4]], [[4m5a]] – bgRIP + arginine derivative<br />
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| **[[3n3x]] – baRIP + polypeptide <br />
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| **[[3n2d]] – bgRIP + polypeptide <br />
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| *Type 1 ribosome inactivating protein other complexes
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| **[[3n31]], [[3n5d]], [[3n31]], [[3nfm]], [[3njs]], [[3nx9]], [[3n1d]] – baRIP + sugar <br />
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| **[[3v14]], [[4fz9]], [[4guw]], [[4hoa]] – bgRIP + sugar <br />
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| **[[4lro]] – bgRIP + spermidine<br />
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| **[[3sj6]] – bgRIP + oxalane derivative<br />
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| **[[3u6t]] – bgRIP + kanamycin<br />
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| **[[3u8f]] – bgRIP + mycolic acid<br />
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| **[[4h0z]] – bgRIP + acetyl-muramic acid<br />
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| **[[4jtp]] – bgRIP + ascorbic acid<br />
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| **[[4k2z]] – bgRIP + methylethylamine<br />
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| **[[4kl4]] – bgRIP + PEG<br />
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| **[[4jtb]] – bgRIP + phosphate<br />
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| **[[4lwx]] – bgRIP + peptidoglycan<br />
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| **[[4yp2]] – bgRIP + nicotinamide<br />
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| *Momorcharin
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| **[[1f8q]], [[1aha]], [[1ahb]], [[1ahc]], [[1mri]] – bpα-RIP – balsam pear <br />
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| **[[1mrg]] – bpα-RIP + adenosine <br />
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| **[[1mrh]] – bpα-RIP + formycin<br />
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| **[[1cf5]] – bpβ-RIP <br />
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| }}
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| == References == | | == References == |
| <references/> | | <references/> |
| | [[Category:Topic Page]] |