8eyd: Difference between revisions

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'''Unreleased structure'''


The entry 8eyd is ON HOLD  until Paper Publication
==Plasmodium falciparum M1 in complex with inhibitor 15ah==
 
<StructureSection load='8eyd' size='340' side='right'caption='[[8eyd]], [[Resolution|resolution]] 1.83&Aring;' scene=''>
Authors: Calic, P.P.S., McGowan, S., Webb, C.T.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8eyd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EYD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EYD FirstGlance]. <br>
Description: Plasmodium falciparum M1 in complex with inhibitor 15ah
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.83&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=X4O:N-[(1R)-1-(4-bromophenyl)-2-(hydroxyamino)-2-oxoethyl]-N~2~-(4-fluorophenyl)glycinamide'>X4O</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
[[Category: Webb, C.T]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8eyd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8eyd OCA], [https://pdbe.org/8eyd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8eyd RCSB], [https://www.ebi.ac.uk/pdbsum/8eyd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8eyd ProSAT]</span></td></tr>
[[Category: Calic, P.P.S]]
</table>
[[Category: Mcgowan, S]]
== Function ==
[https://www.uniprot.org/uniprot/AMP1_PLAFQ AMP1_PLAFQ] Displays aminopeptidase activity with a broad substrate specificity. Preferentially hydrolyzes L-Lys-AMC but also shows strong activity against L-Ala-AMC, L-Arg-AMC and L-Leu-AMC.<ref>PMID:12166515</ref> <ref>PMID:19196988</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Plasmodium falciparum]]
[[Category: Calic PPS]]
[[Category: McGowan S]]
[[Category: Webb CT]]

Latest revision as of 13:25, 25 October 2023

Plasmodium falciparum M1 in complex with inhibitor 15ahPlasmodium falciparum M1 in complex with inhibitor 15ah

Structural highlights

8eyd is a 1 chain structure with sequence from Plasmodium falciparum. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.83Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

AMP1_PLAFQ Displays aminopeptidase activity with a broad substrate specificity. Preferentially hydrolyzes L-Lys-AMC but also shows strong activity against L-Ala-AMC, L-Arg-AMC and L-Leu-AMC.[1] [2]

References

  1. ↑ Allary M, Schrevel J, Florent I. Properties, stage-dependent expression and localization of Plasmodium falciparum M1 family zinc-aminopeptidase. Parasitology. 2002 Jul;125(Pt 1):1-10. PMID:12166515
  2. ↑ McGowan S, Porter CJ, Lowther J, Stack CM, Golding SJ, Skinner-Adams TS, Trenholme KR, Teuscher F, Donnelly SM, Grembecka J, Mucha A, Kafarski P, Degori R, Buckle AM, Gardiner DL, Whisstock JC, Dalton JP. Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase. Proc Natl Acad Sci U S A. 2009 Feb 5. PMID:19196988

8eyd, resolution 1.83Å

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OCA
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