8ex3: Difference between revisions

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'''Unreleased structure'''


The entry 8ex3 is ON HOLD  until Paper Publication
==Plasmodium falciparum M1 in complex with inhibitor 9aa==
 
<StructureSection load='8ex3' size='340' side='right'caption='[[8ex3]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
Authors: Calic, P.P.S., McGowan, S., Webb, C.T.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8ex3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EX3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EX3 FirstGlance]. <br>
Description: Plasmodium falciparum M1 in complex with inhibitor 9aa
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=X10:N-[(1R)-2-(hydroxyamino)-2-oxo-1-(3,4,5-trifluoro[1,1-biphenyl]-4-yl)ethyl]-N~2~-phenylglycinamide'>X10</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
[[Category: Webb, C.T]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ex3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ex3 OCA], [https://pdbe.org/8ex3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ex3 RCSB], [https://www.ebi.ac.uk/pdbsum/8ex3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ex3 ProSAT]</span></td></tr>
[[Category: Calic, P.P.S]]
</table>
[[Category: Mcgowan, S]]
== Function ==
[https://www.uniprot.org/uniprot/AMP1_PLAFQ AMP1_PLAFQ] Displays aminopeptidase activity with a broad substrate specificity. Preferentially hydrolyzes L-Lys-AMC but also shows strong activity against L-Ala-AMC, L-Arg-AMC and L-Leu-AMC.<ref>PMID:12166515</ref> <ref>PMID:19196988</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Plasmodium falciparum]]
[[Category: Calic PPS]]
[[Category: McGowan S]]
[[Category: Webb CT]]

Latest revision as of 13:25, 25 October 2023

Plasmodium falciparum M1 in complex with inhibitor 9aaPlasmodium falciparum M1 in complex with inhibitor 9aa

Structural highlights

8ex3 is a 1 chain structure with sequence from Plasmodium falciparum. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.6Å
Ligands:, , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

AMP1_PLAFQ Displays aminopeptidase activity with a broad substrate specificity. Preferentially hydrolyzes L-Lys-AMC but also shows strong activity against L-Ala-AMC, L-Arg-AMC and L-Leu-AMC.[1] [2]

References

  1. ↑ Allary M, Schrevel J, Florent I. Properties, stage-dependent expression and localization of Plasmodium falciparum M1 family zinc-aminopeptidase. Parasitology. 2002 Jul;125(Pt 1):1-10. PMID:12166515
  2. ↑ McGowan S, Porter CJ, Lowther J, Stack CM, Golding SJ, Skinner-Adams TS, Trenholme KR, Teuscher F, Donnelly SM, Grembecka J, Mucha A, Kafarski P, Degori R, Buckle AM, Gardiner DL, Whisstock JC, Dalton JP. Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase. Proc Natl Acad Sci U S A. 2009 Feb 5. PMID:19196988

8ex3, resolution 1.60Å

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OCA
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