8d1t: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''Unreleased structure'''
-The entry 8d1t is ON HOLD
+==Crystal structure of human USP30 in complex with a covalent inhibitor 552 and a Fab==
+<StructureSection load='8d1t' size='340' side='right'caption='[[8d1t]], [[Resolution|resolution]] 2.94&Aring;' scene=''>
-Authors: Song, X., Butler, J., Li, C., Zhang, K., Zhang, D., Hao, Y.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8d1t]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8D1T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8D1T FirstGlance]. <br>
-Description: Crystal structure of human USP30 in complex with a covalent inhibitor 552 and a Fab
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.94&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PXW:(1R,2R,4S,7E)-7-[amino(sulfanyl)methylidene]-2-{[(1P)-3-chloro-3-(1-cyanocyclopropyl)[1,1-biphenyl]-4-carbonyl]amino}-7-azabicyclo[2.2.1]heptan-7-ium'>PXW</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Butler, J]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8d1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8d1t OCA], [https://pdbe.org/8d1t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8d1t RCSB], [https://www.ebi.ac.uk/pdbsum/8d1t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8d1t ProSAT]</span></td></tr>
-[[Category: Li, C]]
+</table>
-[[Category: Zhang, D]]
+== Function ==
-[[Category: Hao, Y]]
+[https://www.uniprot.org/uniprot/UBP30_HUMAN UBP30_HUMAN] Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy (PubMed:18287522, PubMed:24896179, PubMed:25527291, PubMed:25621951). Preferentially cleaves 'Lys-6'- and 'Lys-11'-linked polyubiquitin chains, 2 types of linkage that participate to mitophagic signaling (PubMed:25621951). Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65' (PubMed:25527291). Acts as negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2 (By similarity).[UniProtKB:Q3UN04]<ref>PMID:18287522</ref> <ref>PMID:24896179</ref> <ref>PMID:25527291</ref> <ref>PMID:25621951</ref>
-[[Category: Song, X]]
+== References ==
-[[Category: Zhang, K]]
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Mus musculus]]
+[[Category: Butler J]]
+[[Category: Hao Y]]
+[[Category: Li C]]
+[[Category: Song X]]
+[[Category: Zhang D]]
+[[Category: Zhang K]]