8cyh: Difference between revisions

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-'''Unreleased structure'''
-The entry 8cyh is ON HOLD  until Paper Publication
+==Novel Anti-Mesothelin Antibodies Enable Crystallography of the Intact Mesothelin Ectodo- main and Engineering of Potent, T cell-engaging Bispecific Therapeutics==
+<StructureSection load='8cyh' size='340' side='right'caption='[[8cyh]], [[Resolution|resolution]] 3.38&Aring;' scene=''>
-Authors: Bandaranayake, A.D., Rupert, P.B., Lin, I., Pilat, K., Ruff, R.O., Friend, D.J., Chan, M.K., Clarke, M., Carter, J., Meshinchi, S., Mehlin, C., Olson, J.M., Strong, R.K., Correnti, C.E.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8cyh]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CYH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CYH FirstGlance]. <br>
-Description: Novel Anti-Mesothelin Antibodies Enable Crystallography of the Intact Mesothelin Ectodo-main and Engineering of Potent, T cell-engaging Bispecific Therapeutics
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.38&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-[[Category: Olson, J.M]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8cyh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8cyh OCA], [https://pdbe.org/8cyh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8cyh RCSB], [https://www.ebi.ac.uk/pdbsum/8cyh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8cyh ProSAT]</span></td></tr>
-[[Category: Ruff, R.O]]
+</table>
-[[Category: Lin, I]]
+== Disease ==
-[[Category: Rupert, P.B]]
+[https://www.uniprot.org/uniprot/MSLN_HUMAN MSLN_HUMAN] Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer.
-[[Category: Bandaranayake, A.D]]
+== Function ==
-[[Category: Pilat, K]]
+[https://www.uniprot.org/uniprot/MSLN_HUMAN MSLN_HUMAN] Membrane-anchored forms may play a role in cellular adhesion.<ref>PMID:8288629</ref> <ref>PMID:14676194</ref>   Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro.<ref>PMID:8288629</ref> <ref>PMID:14676194</ref>
-[[Category: Mehlin, C]]
+== References ==
-[[Category: Strong, R.K]]
+<references/>
-[[Category: Clarke, M]]
+__TOC__
-[[Category: Chan, M.K]]
+</StructureSection>
-[[Category: Friend, D.J]]
+[[Category: Homo sapiens]]
-[[Category: Carter, J]]
+[[Category: Large Structures]]
-[[Category: Correnti, C.E]]
+[[Category: Bandaranayake AD]]
-[[Category: Meshinchi, S]]
+[[Category: Carter J]]
+[[Category: Chan MK]]
+[[Category: Clarke M]]
+[[Category: Correnti CE]]
+[[Category: Friend DJ]]
+[[Category: Lin I]]
+[[Category: Mehlin C]]
+[[Category: Meshinchi S]]
+[[Category: Olson JM]]
+[[Category: Pilat K]]
+[[Category: Ruff RO]]
+[[Category: Rupert PB]]
+[[Category: Strong RK]]