4x6f: Difference between revisions

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 ==CD1a binary complex with sphingomyelin==
-<StructureSection load='4x6f' size='340' side='right' caption='[[4x6f]], [[Resolution|resolution]] 1.91&Aring;' scene=''>
+<StructureSection load='4x6f' size='340' side='right'caption='[[4x6f]], [[Resolution|resolution]] 1.91&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4x6f]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X6F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X6F FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4x6f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X6F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4X6F FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3XU:(4S,7S,23Z)-4-HYDROXY-7-[(1S,2Z)-1-HYDROXYHEXADEC-2-EN-1-YL]-N,N,N-TRIMETHYL-9-OXO-3,5-DIOXA-8-AZA-4-PHOSPHADOTRIACONT-23-EN-1-AMINIUM+4-OXIDE'>3XU</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.91&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4x6b|4x6b]], [[4x6c|4x6c]], [[4x6d|4x6d]], [[4x6e|4x6e]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3XU:(4S,7S,23Z)-4-HYDROXY-7-[(1S,2Z)-1-HYDROXYHEXADEC-2-EN-1-YL]-N,N,N-TRIMETHYL-9-OXO-3,5-DIOXA-8-AZA-4-PHOSPHADOTRIACONT-23-EN-1-AMINIUM+4-OXIDE'>3XU</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x6f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4x6f RCSB], [http://www.ebi.ac.uk/pdbsum/4x6f PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4x6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x6f OCA], [https://pdbe.org/4x6f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4x6f RCSB], [https://www.ebi.ac.uk/pdbsum/4x6f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4x6f ProSAT]</span></td></tr>
 </table>
-== Disease ==
-[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref>   Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
 == Function ==
-[[http://www.uniprot.org/uniprot/CD1A_HUMAN CD1A_HUMAN]] Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.<ref>PMID:11231314</ref> <ref>PMID:16272286</ref> <ref>PMID:18178838</ref>  [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
+[https://www.uniprot.org/uniprot/CD1A_HUMAN CD1A_HUMAN] Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.<ref>PMID:11231314</ref> <ref>PMID:16272286</ref> <ref>PMID:18178838</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 19: / Line 18: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 4x6f" style="background-color:#fffaf0;"></div>
 ==See Also==
-*[[Beta-2 microglobulin|Beta-2 microglobulin]]
+*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
+*[[CD1|CD1]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Birkinshaw, R W]]
+[[Category: Homo sapiens]]
-[[Category: Rossjohn, J]]
+[[Category: Large Structures]]
-[[Category: Cd1a]]
+[[Category: Birkinshaw RW]]
-[[Category: Immune complex]]
+[[Category: Rossjohn J]]
-[[Category: Lipid antigen]]
-[[Category: Tcr]]