2z01: Difference between revisions

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-{{Seed}}
-[[Image:2z01.png|left|200px]]
-<!--
+==Crystal structure of phosphoribosylaminoimidazole synthetase from Geobacillus kaustophilus==
-The line below this paragraph, containing "STRUCTURE_2z01", creates the "Structure Box" on the page.
+<StructureSection load='2z01' size='340' side='right'caption='[[2z01]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2z01]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacillus_kaustophilus Geobacillus kaustophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z01 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Z01 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2z01 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z01 OCA], [https://pdbe.org/2z01 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2z01 RCSB], [https://www.ebi.ac.uk/pdbsum/2z01 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2z01 ProSAT], [https://www.topsan.org/Proteins/RSGI/2z01 TOPSAN]</span></td></tr>
-{{STRUCTURE_2z01|  PDB=2z01  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PUR5_GEOKA PUR5_GEOKA]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z0/2z01_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2z01 ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Crystal structures of 5-aminoimidazole ribonucleotide (AIR) synthetase, also known as PurM, from Thermus thermophilus (Tt) and Geobacillus kaustophilus (Gk) were determined. For TtPurM, the maximum resolution was 2.2 A and the space group was P21212 with four dimers in an asymmetric unit. For GkPurM, the maximum resolution was 2.2 A and the space group was P21212 with one monomer in asymmetric unit. The biological unit is dimer for both TtPurM and GkPurM and the dimer structures were similar to previously determined structures of PurM in general. For TtPurM, approximately 50 residues at the amino terminal were disordered in the crystal structure whereas, for GkPurM, the corresponding region covered the ATP-binding site forming an alpha helix in part, suggesting that the N-terminal region of PurM changes its conformation upon binding of ligands. FGAM binding site was predicted by the docking simulation followed by the MD simulation based on the SO4 2- binding site found in the crystal structure of TtPurM.
-===Crystal structure of phosphoribosylaminoimidazole synthetase from Geobacillus kaustophilus===
+Crystal structures and ligand binding of PurM proteins from Thermus thermophilus and Geobacillus kaustophilus.,Kanagawa M, Baba S, Watanabe Y, Nakagawa N, Ebihara A, Kuramitsu S, Yokoyama S, Sampei GI, Kawai G J Biochem. 2015 Oct 29. pii: mvv107. PMID:26515187<ref>PMID:26515187</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-==About this Structure==
+</div>
-Z01 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Geobacillus_kaustophilus Geobacillus kaustophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z01 OCA].
+<div class="pdbe-citations 2z01" style="background-color:#fffaf0;"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Geobacillus kaustophilus]]
-[[Category: Phosphoribosylformylglycinamidine cyclo-ligase]]
+[[Category: Large Structures]]
-[[Category: Single protein]]
+[[Category: Baba S]]
-[[Category: Baba, S.]]
+[[Category: Kanagawa M]]
-[[Category: Kanagawa, M.]]
+[[Category: Kawai G]]
-[[Category: Kawai, G.]]
+[[Category: Kuramitsu S]]
-[[Category: Kuramitsu, S.]]
+[[Category: Sampei G]]
-[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
+[[Category: Yokoyama S]]
-[[Category: Sampei, G.]]
-[[Category: Yokoyama, S.]]
-[[Category: Alpha and beta protein]]
-[[Category: Cytoplasm]]
-[[Category: Ligase]]
-[[Category: National project on protein structural and functional analyse]]
-[[Category: Nppsfa]]
-[[Category: Purine biosynthesis]]
-[[Category: Riken structural genomics/proteomics initiative]]
-[[Category: Rsgi]]
-[[Category: Structural genomic]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Sep 28 15:45:42 2008''