2yxq: Difference between revisions

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-[[Image:2yxq.jpg|left|200px]]
- {{Structure
+==The plug domain of the SecY protein stablizes the closed state of the translocation channel and maintains a membrane seal==
-|PDB= 2yxq |SIZE=350|CAPTION= <scene name='initialview01'>2yxq</scene>, resolution 3.5&Aring;
+<StructureSection load='2yxq' size='340' side='right'caption='[[2yxq]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND=
+<table><tr><td colspan='2'>[[2yxq]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YXQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YXQ FirstGlance]. <br>
-|ACTIVITY=
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
-|GENE= secY ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2190 Methanocaldococcus jannaschii]), secE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2190 Methanocaldococcus jannaschii]), secG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2190 Methanocaldococcus jannaschii])
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yxq OCA], [https://pdbe.org/2yxq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yxq RCSB], [https://www.ebi.ac.uk/pdbsum/2yxq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yxq ProSAT]</span></td></tr>
-}}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/SECY_METJA SECY_METJA] The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yx/2yxq_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2yxq ConSurf].
+<div style="clear:both"></div>
-'''The plug domain of the SecY protein stablizes the closed state of the translocation channel and maintains a membrane seal'''
+==See Also==
+*[[Preprotein translocase 3D structures|Preprotein translocase 3D structures]]
+__TOC__
-==About this Structure==
+</StructureSection>
-YXQ is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YXQ OCA].
+[[Category: Large Structures]]
-==Reference==
-Puzzle plugged by protein pore plasticity., Minor DL Jr, Mol Cell. 2007 May 25;26(4):459-60. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17531803 17531803]
 [[Category: Methanocaldococcus jannaschii]]
-[[Category: Protein complex]]
+[[Category: Li W]]
-[[Category: Li, W.]]
+[[Category: Schulman S]]
-[[Category: Schulman, S.]]
-[[Category: membrane protein]]
-[[Category: prl mutation]]
-[[Category: protein secretion]]
-[[Category: protein translocation]]
-[[Category: protein transport]]
-[[Category: signal peptide]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:50:13 2008''