2yw6: Difference between revisions
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<StructureSection load='2yw6' size='340' side='right'caption='[[2yw6]], [[Resolution|resolution]] 2.53Å' scene=''> | <StructureSection load='2yw6' size='340' side='right'caption='[[2yw6]], [[Resolution|resolution]] 2.53Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2yw6]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2yw6]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis Mycolicibacterium smegmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YW6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YW6 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.53Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yw6 OCA], [https://pdbe.org/2yw6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yw6 RCSB], [https://www.ebi.ac.uk/pdbsum/2yw6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yw6 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yw6 OCA], [https://pdbe.org/2yw6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yw6 RCSB], [https://www.ebi.ac.uk/pdbsum/2yw6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yw6 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/DPS_MYCSM DPS_MYCSM] Protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction (By similarity). It protects DNA from hydroxyl radical-mediated cleavage. Binds DNA with no apparent sequence specificity without self-aggregation nor promotion of DNA condensation. Is unable to protect DNA from DNase-mediated cleavage.<ref>PMID:12466274</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Chatterji | [[Category: Mycolicibacterium smegmatis]] | ||
[[Category: Gupta | [[Category: Chatterji D]] | ||
[[Category: Roy | [[Category: Gupta S]] | ||
[[Category: Saraswathi | [[Category: Roy S]] | ||
[[Category: Sekar | [[Category: Saraswathi R]] | ||
[[Category: Vijayan | [[Category: Sekar K]] | ||
[[Category: Vijayan M]] | |||