2ri4: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older edit
No edit summary
No edit summary
 
(12 intermediate revisions by the same user not shown)
Line 1: Line 1:
{{Seed}}
[[Image:2ri4.jpg|left|200px]]


<!--
==Crystal Structure determination of Goat Methemoglobin at 2.7 Angstrom==
The line below this paragraph, containing "STRUCTURE_2ri4", creates the "Structure Box" on the page.
<StructureSection load='2ri4' size='340' side='right'caption='[[2ri4]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2ri4]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Capra_hircus Capra hircus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RI4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RI4 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
{{STRUCTURE_2ri4| PDB=2ri4 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ri4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ri4 OCA], [https://pdbe.org/2ri4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ri4 RCSB], [https://www.ebi.ac.uk/pdbsum/2ri4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ri4 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HBA1_CAPHI HBA1_CAPHI] Involved in oxygen transport from the lung to the various peripheral tissues.  Hemopressin acts as an antagonist peptide of the cannabinoid receptor CNR1. Hemopressin-binding efficiently blocks cannabinoid receptor CNR1 and subsequent signaling.[UniProtKB:P01946]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ri/2ri4_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ri4 ConSurf].
<div style="clear:both"></div>


===Crystal Structure determination of Goat Methemoglobin at 2.7 Angstrom===
==See Also==
 
*[[Hemoglobin 3D structures|Hemoglobin 3D structures]]
 
__TOC__
<!--
</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_17909297}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 17909297 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_17909297}}
 
==About this Structure==
2RI4 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Capra_hircus Capra hircus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RI4 OCA].
 
==Reference==
Crystallization of sheep (Ovis aries) and goat (Capra hircus) haemoglobins under unbuffered low-salt conditions., Neelagandan K, Moorthy PS, Balasubramanian M, Ponnuswamy MN, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Oct 1;63(Pt, 10):887-9. Epub 2007 Sep 19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17909297 17909297]
[[Category: Capra hircus]]
[[Category: Capra hircus]]
[[Category: Protein complex]]
[[Category: Large Structures]]
[[Category: Balasubramanian, M.]]
[[Category: Balasubramanian M]]
[[Category: Moorthy, P S.]]
[[Category: Neelagandan K]]
[[Category: Neelagandan, K.]]
[[Category: Ponnuswamy MN]]
[[Category: Ponnuswamy, M N.]]
[[Category: Sathya Moorthy P]]
[[Category: Allosteric mechanism]]
[[Category: Heme]]
[[Category: Iron]]
[[Category: Low oxygen affinity]]
[[Category: Metal-binding]]
[[Category: Methemoglobin]]
[[Category: Oxygen storage]]
[[Category: Oxygen transport]]
[[Category: Polymorphism]]
[[Category: Transport]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 15 14:10:40 2008''

Latest revision as of 12:04, 25 October 2023

Crystal Structure determination of Goat Methemoglobin at 2.7 AngstromCrystal Structure determination of Goat Methemoglobin at 2.7 Angstrom

Structural highlights

2ri4 is a 8 chain structure with sequence from Capra hircus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.7Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

HBA1_CAPHI Involved in oxygen transport from the lung to the various peripheral tissues. Hemopressin acts as an antagonist peptide of the cannabinoid receptor CNR1. Hemopressin-binding efficiently blocks cannabinoid receptor CNR1 and subsequent signaling.[UniProtKB:P01946]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2ri4, resolution 2.70Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=2ri4&oldid=3925893"