2pc9: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older edit
No edit summary
No edit summary
 
(15 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:2pc9.jpg|left|200px]]<br /><applet load="2pc9" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2pc9, resolution 2.40&Aring;" />
'''Crystal Structure Of ATP-Dependent Phosphoenolpyruvate Carboxykinase From Thermus thermophilus HB8'''<br />


==About this Structure==
==Crystal Structure Of ATP-Dependent Phosphoenolpyruvate Carboxykinase From Thermus thermophilus HB8==
2PC9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus] with <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=PO4:'>PO4</scene> and <scene name='pdbligand=ATP:'>ATP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Phosphoenolpyruvate_carboxykinase_(ATP) Phosphoenolpyruvate carboxykinase (ATP)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.49 4.1.1.49] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PC9 OCA].
<StructureSection load='2pc9' size='340' side='right'caption='[[2pc9]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
[[Category: Phosphoenolpyruvate carboxykinase (ATP)]]
== Structural highlights ==
[[Category: Single protein]]
<table><tr><td colspan='2'>[[2pc9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PC9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PC9 FirstGlance]. <br>
[[Category: Thermus thermophilus]]
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
[[Category: Kunishima, N.]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pc9 OCA], [https://pdbe.org/2pc9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pc9 RCSB], [https://www.ebi.ac.uk/pdbsum/2pc9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pc9 ProSAT], [https://www.topsan.org/Proteins/RSGI/2pc9 TOPSAN]</span></td></tr>
[[Category: Sugahara, M.]]
</table>
[[Category: ATP]]
== Function ==
[[Category: CA]]
[https://www.uniprot.org/uniprot/PCKA_THET8 PCKA_THET8] Involved in gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA (By similarity).<ref>PMID:16239727</ref>
[[Category: PO4]]
== Evolutionary Conservation ==
[[Category: adenosine triphosphate]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: lyase]]
Check<jmol>
[[Category: national project on protein structural and functional analyses]]
  <jmolCheckbox>
[[Category: nppsfa]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pc/2pc9_consurf.spt"</scriptWhenChecked>
[[Category: phosphoenolpyruvate carboxykinase]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: riken structural genomics/proteomics initiative]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: rsgi]]
  </jmolCheckbox>
[[Category: structural genomics]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pc9 ConSurf].
[[Category: thermus thermophilus hb8]]
<div style="clear:both"></div>


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:28:05 2008''
==See Also==
*[[Phosphoenolpyruvate carboxykinase 3D structures|Phosphoenolpyruvate carboxykinase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Thermus thermophilus HB8]]
[[Category: Kunishima N]]
[[Category: Sugahara M]]

Latest revision as of 12:00, 25 October 2023

Crystal Structure Of ATP-Dependent Phosphoenolpyruvate Carboxykinase From Thermus thermophilus HB8Crystal Structure Of ATP-Dependent Phosphoenolpyruvate Carboxykinase From Thermus thermophilus HB8

Structural highlights

2pc9 is a 4 chain structure with sequence from Thermus thermophilus HB8. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.4Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

PCKA_THET8 Involved in gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA (By similarity).[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Sugahara M, Ohshima N, Ukita Y, Sugahara M, Kunishima N. Structure of ATP-dependent phosphoenolpyruvate carboxykinase from Thermus thermophilus HB8 showing the structural basis of induced fit and thermostability. Acta Crystallogr D Biol Crystallogr. 2005 Nov;61(Pt 11):1500-7. Epub 2005, Oct 19. PMID:16239727 doi:10.1107/S090744490502651X

2pc9, resolution 2.40Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=2pc9&oldid=3925702"