2p5c: Difference between revisions
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==Crystal structure of PH0725 from Pyrococcus horikoshii OT3== | ==Crystal structure of PH0725 from Pyrococcus horikoshii OT3== | ||
<StructureSection load='2p5c' size='340' side='right' caption='[[2p5c]], [[Resolution|resolution]] 2.40Å' scene=''> | <StructureSection load='2p5c' size='340' side='right'caption='[[2p5c]], [[Resolution|resolution]] 2.40Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2p5c]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2p5c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_horikoshii_OT3 Pyrococcus horikoshii OT3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P5C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P5C FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p5c OCA], [https://pdbe.org/2p5c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p5c RCSB], [https://www.ebi.ac.uk/pdbsum/2p5c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p5c ProSAT], [https://www.topsan.org/Proteins/RSGI/2p5c TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/DPHB_PYRHO DPHB_PYRHO] S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.<ref>PMID:20873788</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Pyrococcus horikoshii]] | [[Category: Pyrococcus horikoshii OT3]] | ||
[[Category: Kunishima | [[Category: Kunishima N]] | ||
[[Category: Matsuura | [[Category: Matsuura Y]] | ||
[[Category: Ono | [[Category: Ono N]] | ||
[[Category: Taketa M]] | |||
[[Category: Taketa | [[Category: Yamamoto H]] | ||
[[Category: Yamamoto | |||