2nli: Difference between revisions

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 ==Crystal Structure of the complex between L-lactate oxidase and a substrate analogue at 1.59 angstrom resolution==
-<StructureSection load='2nli' size='340' side='right' caption='[[2nli]], [[Resolution|resolution]] 1.59&Aring;' scene=''>
+<StructureSection load='2nli' size='340' side='right'caption='[[2nli]], [[Resolution|resolution]] 1.59&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2nli]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"gaffkya_homari"_hitchner_and_snieszko_1947 "gaffkya homari" hitchner and snieszko 1947]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NLI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NLI FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2nli]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aerococcus_viridans Aerococcus viridans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NLI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NLI FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=LAC:LACTIC+ACID'>LAC</scene>, <scene name='pdbligand=PEO:HYDROGEN+PEROXIDE'>PEO</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.59&#8491;</td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lactate_2-monooxygenase Lactate 2-monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.12.4 1.13.12.4] </span></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=LAC:LACTIC+ACID'>LAC</scene>, <scene name='pdbligand=PEO:HYDROGEN+PEROXIDE'>PEO</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nli FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nli OCA], [http://pdbe.org/2nli PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2nli RCSB], [http://www.ebi.ac.uk/pdbsum/2nli PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2nli ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nli FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nli OCA], [https://pdbe.org/2nli PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nli RCSB], [https://www.ebi.ac.uk/pdbsum/2nli PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nli ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/LOX_AERVM LOX_AERVM] Catalyzes the oxidation of (S)-lactate (L-lactate) to pyruvate, with a reduction of O2 to H2O2 (Ref.1, PubMed:27302031, PubMed:25423902, PubMed:2818595, PubMed:8589073, PubMed:26260739). Cannot oxidize D-lactate, glycolate, and D,L-2-hydroxybutanoate (PubMed:2818595). May be involved in the utilization of L-lactate as an energy source for growth (By similarity).[UniProtKB:O33655]<ref>PMID:25423902</ref> <ref>PMID:26260739</ref> <ref>PMID:27302031</ref> <ref>PMID:2818595</ref> <ref>PMID:8589073</ref> [UniProtKB:O33655]
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 27: / Line 29: @@
 </div>
 <div class="pdbe-citations 2nli" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Monooxygenase 3D structures|Monooxygenase 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Gaffkya homari hitchner and snieszko 1947]]
+[[Category: Aerococcus viridans]]
-[[Category: Lactate 2-monooxygenase]]
+[[Category: Large Structures]]
-[[Category: Balasundaresan, D]]
+[[Category: Balasundaresan D]]
-[[Category: Furuichi, M]]
+[[Category: Furuichi M]]
-[[Category: Kaneko, H]]
+[[Category: Kaneko H]]
-[[Category: Kumar, P K.R]]
+[[Category: Kumar PKR]]
-[[Category: Minagawa, H]]
+[[Category: Minagawa H]]
-[[Category: Mizuno, H]]
+[[Category: Mizuno H]]
-[[Category: Suzuki, N]]
+[[Category: Suzuki N]]
-[[Category: Waga, I]]
+[[Category: Waga I]]
-[[Category: Watanabe, Y]]
+[[Category: Watanabe Y]]
-[[Category: Yoshida, Y]]
+[[Category: Yoshida Y]]
-[[Category: D-lactate]]
-[[Category: Flavoenzyme]]
-[[Category: Fmn]]
-[[Category: L-lactate oxidase]]
-[[Category: Oxidoreductase]]