2huq: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:2huq.jpg|left|200px]]<br /><applet load="2huq" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="2huq, resolution 2.20&Aring;" />
-'''Crystal structure of PH0725 from Pyrococcus horikoshii OT3'''<br />
-==About this Structure==
+==Crystal structure of PH0725 from Pyrococcus horikoshii OT3==
-HUQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii] with PT and SAH as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Diphthine_synthase Diphthine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.98 2.1.1.98] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2HUQ OCA].
+<StructureSection load='2huq' size='340' side='right'caption='[[2huq]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-[[Category: Diphthine synthase]]
+== Structural highlights ==
-[[Category: Pyrococcus horikoshii]]
+<table><tr><td colspan='2'>[[2huq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_horikoshii_OT3 Pyrococcus horikoshii OT3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HUQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HUQ FirstGlance]. <br>
-[[Category: Single protein]]
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
-[[Category: Karthe, P.]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
-[[Category: Kumarevel, T.S.]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2huq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2huq OCA], [https://pdbe.org/2huq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2huq RCSB], [https://www.ebi.ac.uk/pdbsum/2huq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2huq ProSAT], [https://www.topsan.org/Proteins/RSGI/2huq TOPSAN]</span></td></tr>
-[[Category: Kunishima, N.]]
+</table>
-[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
+== Function ==
-[[Category: Sugahara, M.]]
+[https://www.uniprot.org/uniprot/DPHB_PYRHO DPHB_PYRHO] S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.<ref>PMID:20873788</ref>
-[[Category: PT]]
+== Evolutionary Conservation ==
-[[Category: SAH]]
+[[Image:Consurf_key_small.gif|200px|right]]
-[[Category: national project on protein structural and functional analyses]]
+Check<jmol>
-[[Category: nppsfa]]
+  <jmolCheckbox>
-[[Category: pyrococcus horikoshii ot3]]
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hu/2huq_consurf.spt"</scriptWhenChecked>
-[[Category: riken structural genomics/proteomics initiative]]
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-[[Category: rsgi]]
+    <text>to colour the structure by Evolutionary Conservation</text>
-[[Category: structural genomics]]
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2huq ConSurf].
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 11:59:50 2007''
+<div style="clear:both"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Pyrococcus horikoshii OT3]]
+[[Category: Karthe P]]
+[[Category: Kumarevel TS]]
+[[Category: Kunishima N]]
+[[Category: Sugahara M]]