2huq: Difference between revisions

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-[[Image:2huq.jpg|left|200px]]
- {{Structure
+==Crystal structure of PH0725 from Pyrococcus horikoshii OT3==
-|PDB= 2huq |SIZE=350|CAPTION= <scene name='initialview01'>2huq</scene>, resolution 2.20&Aring;
+<StructureSection load='2huq' size='340' side='right'caption='[[2huq]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND= <scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene> and <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>
+<table><tr><td colspan='2'>[[2huq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_horikoshii_OT3 Pyrococcus horikoshii OT3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HUQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HUQ FirstGlance]. <br>
-|ACTIVITY= [http://en.wikipedia.org/wiki/Diphthine_synthase Diphthine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.98 2.1.1.98]
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
-|GENE=
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
-}}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2huq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2huq OCA], [https://pdbe.org/2huq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2huq RCSB], [https://www.ebi.ac.uk/pdbsum/2huq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2huq ProSAT], [https://www.topsan.org/Proteins/RSGI/2huq TOPSAN]</span></td></tr>
+</table>
-'''Crystal structure of PH0725 from Pyrococcus horikoshii OT3'''
+== Function ==
+[https://www.uniprot.org/uniprot/DPHB_PYRHO DPHB_PYRHO] S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.<ref>PMID:20873788</ref>
+== Evolutionary Conservation ==
-==About this Structure==
+[[Image:Consurf_key_small.gif|200px|right]]
-HUQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HUQ OCA].
+Check<jmol>
-[[Category: Diphthine synthase]]
+  <jmolCheckbox>
-[[Category: Pyrococcus horikoshii]]
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hu/2huq_consurf.spt"</scriptWhenChecked>
-[[Category: Single protein]]
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-[[Category: Karthe, P.]]
+    <text>to colour the structure by Evolutionary Conservation</text>
-[[Category: Kumarevel, T S.]]
+  </jmolCheckbox>
-[[Category: Kunishima, N.]]
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2huq ConSurf].
-[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
+<div style="clear:both"></div>
-[[Category: Sugahara, M.]]
+== References ==
-[[Category: PT]]
+<references/>
-[[Category: SAH]]
+__TOC__
-[[Category: national project on protein structural and functional analyse]]
+</StructureSection>
-[[Category: nppsfa]]
+[[Category: Large Structures]]
-[[Category: pyrococcus horikoshii ot3]]
+[[Category: Pyrococcus horikoshii OT3]]
-[[Category: riken structural genomics/proteomics initiative]]
+[[Category: Karthe P]]
-[[Category: rsgi]]
+[[Category: Kumarevel TS]]
-[[Category: structural genomic]]
+[[Category: Kunishima N]]
+[[Category: Sugahara M]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:21:50 2008''