2f12: Difference between revisions

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<StructureSection load='2f12' size='340' side='right'caption='[[2f12]], [[Resolution|resolution]] 2.27&Aring;' scene=''>
<StructureSection load='2f12' size='340' side='right'caption='[[2f12]], [[Resolution|resolution]] 2.27&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2f12]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F12 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F12 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2f12]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F12 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F12 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HTM:6-(3-HYDROXYPROPOXY)-5-ACETAMIDO-5,6-DIHYDRO-4-HYDROXY-4H-PYRAN-2-CARBOXYLIC+ACID'>HTM</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.27&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1snt|1snt]], [[1so7|1so7]], [[1vcu|1vcu]], [[2f0z|2f0z]], [[2f10|2f10]], [[2f11|2f11]], [[2f13|2f13]], [[2f24|2f24]], [[2f25|2f25]], [[2f26|2f26]], [[2f27|2f27]], [[2f28|2f28]], [[2f29|2f29]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HTM:6-(3-HYDROXYPROPOXY)-5-ACETAMIDO-5,6-DIHYDRO-4-HYDROXY-4H-PYRAN-2-CARBOXYLIC+ACID'>HTM</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f12 OCA], [https://pdbe.org/2f12 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f12 RCSB], [https://www.ebi.ac.uk/pdbsum/2f12 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f12 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f12 OCA], [https://pdbe.org/2f12 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f12 RCSB], [https://www.ebi.ac.uk/pdbsum/2f12 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f12 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/NEUR2_HUMAN NEUR2_HUMAN]] Hydrolyzes sialylated compounds.  
[https://www.uniprot.org/uniprot/NEUR2_HUMAN NEUR2_HUMAN] Hydrolyzes sialylated compounds.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Exo-alpha-sialidase]]
[[Category: Homo sapiens]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Chavas, L M.G]]
[[Category: Chavas LMG]]
[[Category: Dyason, J C]]
[[Category: Dyason JC]]
[[Category: Fusi, P]]
[[Category: Fusi P]]
[[Category: Itzstein, M von]]
[[Category: Kato R]]
[[Category: Kato, R]]
[[Category: Mann MC]]
[[Category: Mann, M C]]
[[Category: Monti E]]
[[Category: Monti, E]]
[[Category: Tettamanti G]]
[[Category: Tettamanti, G]]
[[Category: Thomson RJ]]
[[Category: Thomson, R J]]
[[Category: Tringali C]]
[[Category: Tringali, C]]
[[Category: Venerando B]]
[[Category: Venerando, B]]
[[Category: Wakatsuki S]]
[[Category: Wakatsuki, S]]
[[Category: Von Itzstein M]]
[[Category: Drug design]]
[[Category: Hydrolase]]
[[Category: Influenza virus]]
[[Category: Neuraminidase]]
[[Category: Sialidase]]

Latest revision as of 11:44, 25 October 2023

Crystal Structure of the Human Sialidase Neu2 in Complex with 3- hydroxypropyl ether mimetic InhibitorCrystal Structure of the Human Sialidase Neu2 in Complex with 3- hydroxypropyl ether mimetic Inhibitor

Structural highlights

2f12 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.27Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

NEUR2_HUMAN Hydrolyzes sialylated compounds.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2f12, resolution 2.27Å

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OCA
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