2f12: Difference between revisions

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-[[Image:2f12.jpg|left|200px]]
- {{Structure
+==Crystal Structure of the Human Sialidase Neu2 in Complex with 3- hydroxypropyl ether mimetic Inhibitor==
-|PDB= 2f12 |SIZE=350|CAPTION= <scene name='initialview01'>2f12</scene>, resolution 2.270&Aring;
+<StructureSection load='2f12' size='340' side='right'caption='[[2f12]], [[Resolution|resolution]] 2.27&Aring;' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene> and <scene name='pdbligand=HTM:6-(3-HYDROXYPROPOXY)-5-ACETAMIDO-5,6-DIHYDRO-4-HYDROXY-4H-PYRAN-2-CARBOXYLIC ACID'>HTM</scene>
+<table><tr><td colspan='2'>[[2f12]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F12 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F12 FirstGlance]. <br>
-|ACTIVITY= [http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18]
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.27&#8491;</td></tr>
-|GENE=
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HTM:6-(3-HYDROXYPROPOXY)-5-ACETAMIDO-5,6-DIHYDRO-4-HYDROXY-4H-PYRAN-2-CARBOXYLIC+ACID'>HTM</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-}}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f12 OCA], [https://pdbe.org/2f12 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f12 RCSB], [https://www.ebi.ac.uk/pdbsum/2f12 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f12 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/NEUR2_HUMAN NEUR2_HUMAN] Hydrolyzes sialylated compounds.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f1/2f12_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f12 ConSurf].
+<div style="clear:both"></div>
-'''Crystal Structure of the Human Sialidase Neu2 in Complex with 3- hydroxypropyl ether mimetic Inhibitor'''
+==See Also==
+*[[Neuraminidase 3D structures|Neuraminidase 3D structures]]
+__TOC__
-==About this Structure==
+</StructureSection>
-F12 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F12 OCA].
-[[Category: Exo-alpha-sialidase]]
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Chavas, L M.G.]]
+[[Category: Chavas LMG]]
-[[Category: Dyason, J C.]]
+[[Category: Dyason JC]]
-[[Category: Fusi, P.]]
+[[Category: Fusi P]]
-[[Category: Itzstein, M von.]]
+[[Category: Kato R]]
-[[Category: Kato, R.]]
+[[Category: Mann MC]]
-[[Category: Mann, M C.]]
+[[Category: Monti E]]
-[[Category: Monti, E.]]
+[[Category: Tettamanti G]]
-[[Category: Tettamanti, G.]]
+[[Category: Thomson RJ]]
-[[Category: Thomson, R J.]]
+[[Category: Tringali C]]
-[[Category: Tringali, C.]]
+[[Category: Venerando B]]
-[[Category: Venerando, B.]]
+[[Category: Wakatsuki S]]
-[[Category: Wakatsuki, S.]]
+[[Category: Von Itzstein M]]
-[[Category: HTM]]
-[[Category: PO4]]
-[[Category: drug design]]
-[[Category: influenza virus]]
-[[Category: neuraminidase]]
-[[Category: sialidase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:46:46 2008''