2f12: Difference between revisions

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 ==Crystal Structure of the Human Sialidase Neu2 in Complex with 3- hydroxypropyl ether mimetic Inhibitor==
-<StructureSection load='2f12' size='340' side='right' caption='[[2f12]], [[Resolution|resolution]] 2.27&Aring;' scene=''>
+<StructureSection load='2f12' size='340' side='right'caption='[[2f12]], [[Resolution|resolution]] 2.27&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2f12]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F12 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2F12 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2f12]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F12 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F12 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HTM:6-(3-HYDROXYPROPOXY)-5-ACETAMIDO-5,6-DIHYDRO-4-HYDROXY-4H-PYRAN-2-CARBOXYLIC+ACID'>HTM</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.27&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1snt|1snt]], [[1so7|1so7]], [[1vcu|1vcu]], [[2f0z|2f0z]], [[2f10|2f10]], [[2f11|2f11]], [[2f13|2f13]], [[2f24|2f24]], [[2f25|2f25]], [[2f26|2f26]], [[2f27|2f27]], [[2f28|2f28]], [[2f29|2f29]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HTM:6-(3-HYDROXYPROPOXY)-5-ACETAMIDO-5,6-DIHYDRO-4-HYDROXY-4H-PYRAN-2-CARBOXYLIC+ACID'>HTM</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f12 OCA], [https://pdbe.org/2f12 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f12 RCSB], [https://www.ebi.ac.uk/pdbsum/2f12 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f12 ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f12 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2f12 RCSB], [http://www.ebi.ac.uk/pdbsum/2f12 PDBsum]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/NEUR2_HUMAN NEUR2_HUMAN]] Hydrolyzes sialylated compounds.
+[https://www.uniprot.org/uniprot/NEUR2_HUMAN NEUR2_HUMAN] Hydrolyzes sialylated compounds.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
 Check<jmol>
    <jmolCheckbox>
-     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f1/2f12_consurf.spt"</scriptWhenChecked>
+     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f1/2f12_consurf.spt"</scriptWhenChecked>
      <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
      <text>to colour the structure by Evolutionary Conservation</text>
    </jmolCheckbox>
-</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f12 ConSurf].
 <div style="clear:both"></div>
 ==See Also==
-*[[Neuraminidase|Neuraminidase]]
+*[[Neuraminidase 3D structures|Neuraminidase 3D structures]]
 __TOC__
 </StructureSection>
-[[Category: Exo-alpha-sialidase]]
 [[Category: Homo sapiens]]
-[[Category: Chavas, L M.G]]
+[[Category: Large Structures]]
-[[Category: Dyason, J C]]
+[[Category: Chavas LMG]]
-[[Category: Fusi, P]]
+[[Category: Dyason JC]]
-[[Category: Itzstein, M von]]
+[[Category: Fusi P]]
-[[Category: Kato, R]]
+[[Category: Kato R]]
-[[Category: Mann, M C]]
+[[Category: Mann MC]]
-[[Category: Monti, E]]
+[[Category: Monti E]]
-[[Category: Tettamanti, G]]
+[[Category: Tettamanti G]]
-[[Category: Thomson, R J]]
+[[Category: Thomson RJ]]
-[[Category: Tringali, C]]
+[[Category: Tringali C]]
-[[Category: Venerando, B]]
+[[Category: Venerando B]]
-[[Category: Wakatsuki, S]]
+[[Category: Wakatsuki S]]
-[[Category: Drug design]]
+[[Category: Von Itzstein M]]
-[[Category: Hydrolase]]
-[[Category: Influenza virus]]
-[[Category: Neuraminidase]]
-[[Category: Sialidase]]