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==Crystal Structure of the Human Sialidase Neu2 in Complex with Peramivir inhibitor== | ==Crystal Structure of the Human Sialidase Neu2 in Complex with Peramivir inhibitor== | ||
<StructureSection load='2f10' size='340' side='right' caption='[[2f10]], [[Resolution|resolution]] 2.90Å' scene=''> | <StructureSection load='2f10' size='340' side='right'caption='[[2f10]], [[Resolution|resolution]] 2.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2f10]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2f10]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F10 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F10 FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BCZ:3-(1-ACETYLAMINO-2-ETHYL-BUTYL)-4-GUANIDINO-2-HYDROXY-CYCLOPENTANECARBOXYLIC+ACID'>BCZ</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BCZ:3-(1-ACETYLAMINO-2-ETHYL-BUTYL)-4-GUANIDINO-2-HYDROXY-CYCLOPENTANECARBOXYLIC+ACID'>BCZ</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |||
<tr | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f10 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f10 OCA], [https://pdbe.org/2f10 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f10 RCSB], [https://www.ebi.ac.uk/pdbsum/2f10 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f10 ProSAT]</span></td></tr> | ||
</table> | |||
<table> | == Function == | ||
[https://www.uniprot.org/uniprot/NEUR2_HUMAN NEUR2_HUMAN] Hydrolyzes sialylated compounds. | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f1/2f10_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f1/2f10_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f10 ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
*[[Neuraminidase|Neuraminidase]] | *[[Neuraminidase 3D structures|Neuraminidase 3D structures]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Chavas | [[Category: Large Structures]] | ||
[[Category: Colman | [[Category: Chavas LMG]] | ||
[[Category: Fusi | [[Category: Colman PM]] | ||
[[Category: Kato | [[Category: Fusi P]] | ||
[[Category: McKimm-Breschkin | [[Category: Kato R]] | ||
[[Category: Monti | [[Category: McKimm-Breschkin J]] | ||
[[Category: Tettamanti | [[Category: Monti E]] | ||
[[Category: Tringali | [[Category: Tettamanti G]] | ||
[[Category: Venerando | [[Category: Tringali C]] | ||
[[Category: Wakatsuki | [[Category: Venerando B]] | ||
[[Category: Wakatsuki S]] | |||
Latest revision as of 11:44, 25 October 2023
Crystal Structure of the Human Sialidase Neu2 in Complex with Peramivir inhibitorCrystal Structure of the Human Sialidase Neu2 in Complex with Peramivir inhibitor
Structural highlights
FunctionNEUR2_HUMAN Hydrolyzes sialylated compounds. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also |
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