2eit: Difference between revisions

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-[[Image:2eit.jpg|left|200px]]
- {{Structure
+==Crystal analysis of delta1-pyrroline-5-carboxylate dehydrogenase from Thermus thermophilus with bound L-alanine and NAD==
-|PDB= 2eit |SIZE=350|CAPTION= <scene name='initialview01'>2eit</scene>, resolution 1.65&Aring;
+<StructureSection load='2eit' size='340' side='right'caption='[[2eit]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND= <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ALA:ALANINE'>ALA</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>
+<table><tr><td colspan='2'>[[2eit]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EIT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EIT FirstGlance]. <br>
-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/1-pyrroline-5-carboxylate_dehydrogenase 1-pyrroline-5-carboxylate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.12 1.5.1.12] </span>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
-|GENE=
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ALA:ALANINE'>ALA</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
-|DOMAIN=
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2eit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eit OCA], [https://pdbe.org/2eit PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2eit RCSB], [https://www.ebi.ac.uk/pdbsum/2eit PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2eit ProSAT], [https://www.topsan.org/Proteins/RSGI/2eit TOPSAN]</span></td></tr>
-|RELATEDENTRY=[[2eii|2EII]]
+</table>
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eit OCA], [http://www.ebi.ac.uk/pdbsum/2eit PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2eit RCSB]</span>
+== Function ==
-}}
+[https://www.uniprot.org/uniprot/Q5SI02_THET8 Q5SI02_THET8]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ei/2eit_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2eit ConSurf].
+<div style="clear:both"></div>
-'''Crystal analysis of delta1-pyrroline-5-carboxylate dehydrogenase from Thermus thermophilus with bound L-alanine and NAD'''
+==See Also==
+*[[Pyrroline-5-carboxylate dehydrogenase|Pyrroline-5-carboxylate dehydrogenase]]
+__TOC__
-==About this Structure==
+</StructureSection>
-EIT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EIT OCA].
+[[Category: Large Structures]]
-[[Category: 1-pyrroline-5-carboxylate dehydrogenase]]
+[[Category: Thermus thermophilus HB8]]
-[[Category: Single protein]]
+[[Category: Inagaki E]]
-[[Category: Thermus thermophilus]]
+[[Category: Sakamoto K]]
-[[Category: Inagaki, E.]]
+[[Category: Yokoyama S]]
-[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
-[[Category: Sakamoto, K.]]
-[[Category: Yokoyama, S.]]
-[[Category: enzyme-coenzyme-inhibitor ternary complex]]
-[[Category: national project on protein structural and functional analyse]]
-[[Category: nppsfa]]
-[[Category: oxidoreductase]]
-[[Category: riken structural genomics/proteomics initiative]]
-[[Category: rsgi]]
-[[Category: structural genomic]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:49:44 2008''