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[[Image:2ehj.jpg|left|200px]]


{{Structure
==Structure of Uracil phosphoribosyl transferase==
|PDB= 2ehj |SIZE=350|CAPTION= <scene name='initialview01'>2ehj</scene>, resolution 2.80&Aring;
<StructureSection load='2ehj' size='340' side='right'caption='[[2ehj]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
|SITE= <scene name='pdbsite=AC1:So4+Binding+Site+For+Residue+A+209'>AC1</scene>, <scene name='pdbsite=AC2:So4+Binding+Site+For+Residue+B+209'>AC2</scene>, <scene name='pdbsite=AC3:So4+Binding+Site+For+Residue+C+209'>AC3</scene>, <scene name='pdbsite=AC4:So4+Binding+Site+For+Residue+D+209'>AC4</scene>, <scene name='pdbsite=AC5:So4+Binding+Site+For+Residue+A+210'>AC5</scene>, <scene name='pdbsite=AC6:So4+Binding+Site+For+Residue+B+210'>AC6</scene>, <scene name='pdbsite=AC7:So4+Binding+Site+For+Residue+C+210'>AC7</scene>, <scene name='pdbsite=AC8:So4+Binding+Site+For+Residue+D+210'>AC8</scene>, <scene name='pdbsite=AC9:So4+Binding+Site+For+Residue+A+211'>AC9</scene>, <scene name='pdbsite=BC1:So4+Binding+Site+For+Residue+C+211'>BC1</scene>, <scene name='pdbsite=BC2:So4+Binding+Site+For+Residue+D+211'>BC2</scene>, <scene name='pdbsite=BC3:So4+Binding+Site+For+Residue+A+212'>BC3</scene>, <scene name='pdbsite=BC4:So4+Binding+Site+For+Residue+B+211'>BC4</scene>, <scene name='pdbsite=BC5:So4+Binding+Site+For+Residue+C+212'>BC5</scene>, <scene name='pdbsite=BC6:So4+Binding+Site+For+Residue+D+212'>BC6</scene>, <scene name='pdbsite=BC7:So4+Binding+Site+For+Residue+D+213'>BC7</scene>, <scene name='pdbsite=BC8:So4+Binding+Site+For+Residue+C+213'>BC8</scene>, <scene name='pdbsite=BC9:So4+Binding+Site+For+Residue+A+213'>BC9</scene> and <scene name='pdbsite=CC1:So4+Binding+Site+For+Residue+B+212'>CC1</scene>
== Structural highlights ==
|LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene>
<table><tr><td colspan='2'>[[2ehj]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EHJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EHJ FirstGlance]. <br>
|ACTIVITY= [http://en.wikipedia.org/wiki/Uracil_phosphoribosyltransferase Uracil phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.9 2.4.2.9]
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ehj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ehj OCA], [https://pdbe.org/2ehj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ehj RCSB], [https://www.ebi.ac.uk/pdbsum/2ehj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ehj ProSAT], [https://www.topsan.org/Proteins/RSGI/2ehj TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/UPP_ECOLI UPP_ECOLI] Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.[HAMAP-Rule:MF_01218_B]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eh/2ehj_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ehj ConSurf].
<div style="clear:both"></div>


'''Structure of Uracil phosphoribosyl transferase'''
==See Also==
 
*[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
2EHJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EHJ OCA].
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Uracil phosphoribosyltransferase]]
[[Category: Lokanath NK]]
[[Category: Lokanath, N K.]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: SO4]]
[[Category: national project on protein structural and functional analyse]]
[[Category: nppsfa]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rsgi]]
[[Category: structural genomic]]
[[Category: uracil phosphoribosyl transferase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:40:14 2008''

Latest revision as of 11:40, 25 October 2023

Structure of Uracil phosphoribosyl transferaseStructure of Uracil phosphoribosyl transferase

Structural highlights

2ehj is a 4 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.8Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

UPP_ECOLI Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.[HAMAP-Rule:MF_01218_B]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2ehj, resolution 2.80Å

Drag the structure with the mouse to rotate

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