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[[Image:2ef1.jpg|left|200px]]


{{Structure
==Crystal structure of the extracellular domain of human CD38==
|PDB= 2ef1 |SIZE=350|CAPTION= <scene name='initialview01'>2ef1</scene>, resolution 2.40&Aring;
<StructureSection load='2ef1' size='340' side='right'caption='[[2ef1]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>
<table><tr><td colspan='2'>[[2ef1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2df1 2df1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EF1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EF1 FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_nucleosidase NAD(+) nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.5 3.2.2.5] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
|GENE= CD38 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ef1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ef1 OCA], [https://pdbe.org/2ef1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ef1 RCSB], [https://www.ebi.ac.uk/pdbsum/2ef1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ef1 ProSAT], [https://www.topsan.org/Proteins/RSGI/2ef1 TOPSAN]</span></td></tr>
|RELATEDENTRY=
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ef1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ef1 OCA], [http://www.ebi.ac.uk/pdbsum/2ef1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ef1 RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/CD38_HUMAN CD38_HUMAN] Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ef/2ef1_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ef1 ConSurf].
<div style="clear:both"></div>


'''Crystal structure of the extracellular domain of human CD38'''
==See Also==
 
*[[Cluster of Differentiation CD38|Cluster of Differentiation CD38]]
 
__TOC__
==About this Structure==
</StructureSection>
2EF1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry 2DF1. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EF1 OCA].
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: NAD(+) nucleosidase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Hara-Yokoyama M]]
[[Category: Hara-Yokoyama, M.]]
[[Category: Katada T]]
[[Category: Katada, T.]]
[[Category: Kukimoto-Niino M]]
[[Category: Kukimoto-Niino, M.]]
[[Category: Murayama K]]
[[Category: Murayama, K.]]
[[Category: Nureki O]]
[[Category: Nureki, O.]]
[[Category: Shirouzu M]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Yokoyama S]]
[[Category: Shirouzu, M.]]
[[Category: Yokoyama, S.]]
[[Category: cell sueface antigen]]
[[Category: hydrolase]]
[[Category: national project on protein structural and functional analyse]]
[[Category: nppsfa]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rsgi]]
[[Category: structural genomic]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:48:07 2008''

Latest revision as of 11:39, 25 October 2023

Crystal structure of the extracellular domain of human CD38Crystal structure of the extracellular domain of human CD38

Structural highlights

2ef1 is a 2 chain structure with sequence from Homo sapiens. This structure supersedes the now removed PDB entry 2df1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.4Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

CD38_HUMAN Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2ef1, resolution 2.40Å

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