2ef1: Difference between revisions

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[[Image:2ef1.png|left|200px]]


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==Crystal structure of the extracellular domain of human CD38==
The line below this paragraph, containing "STRUCTURE_2ef1", creates the "Structure Box" on the page.
<StructureSection load='2ef1' size='340' side='right'caption='[[2ef1]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2ef1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2df1 2df1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EF1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EF1 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
{{STRUCTURE_2ef1|  PDB=2ef1  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ef1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ef1 OCA], [https://pdbe.org/2ef1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ef1 RCSB], [https://www.ebi.ac.uk/pdbsum/2ef1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ef1 ProSAT], [https://www.topsan.org/Proteins/RSGI/2ef1 TOPSAN]</span></td></tr>
 
</table>
===Crystal structure of the extracellular domain of human CD38===
== Function ==
 
[https://www.uniprot.org/uniprot/CD38_HUMAN CD38_HUMAN] Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
 
== Evolutionary Conservation ==
==About this Structure==
[[Image:Consurf_key_small.gif|200px|right]]
[[2ef1]] is a 2 chain structure of [[ADP-ribosyl cyclase 1]] and [[Cluster of Differentiation 38]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2df1 2df1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EF1 OCA].  
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ef/2ef1_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ef1 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[ADP-ribosyl cyclase 1]]
*[[Cluster of Differentiation CD38|Cluster of Differentiation CD38]]
*[[Cluster of Differentiation 38]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Hara-Yokoyama, M.]]
[[Category: Large Structures]]
[[Category: Katada, T.]]
[[Category: Hara-Yokoyama M]]
[[Category: Kukimoto-Niino, M.]]
[[Category: Katada T]]
[[Category: Murayama, K.]]
[[Category: Kukimoto-Niino M]]
[[Category: Nureki, O.]]
[[Category: Murayama K]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Nureki O]]
[[Category: Shirouzu, M.]]
[[Category: Shirouzu M]]
[[Category: Yokoyama, S.]]
[[Category: Yokoyama S]]
[[Category: Cell sueface antigen]]
[[Category: Hydrolase]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Riken structural genomics/proteomics initiative]]
[[Category: Rsgi]]
[[Category: Structural genomic]]

Latest revision as of 11:39, 25 October 2023

Crystal structure of the extracellular domain of human CD38Crystal structure of the extracellular domain of human CD38

Structural highlights

2ef1 is a 2 chain structure with sequence from Homo sapiens. This structure supersedes the now removed PDB entry 2df1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.4Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

CD38_HUMAN Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2ef1, resolution 2.40Å

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