2e5c: Difference between revisions
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==Crystal structure of Human NMPRTase complexed with 5'-phosphoribosyl-1'-pyrophosphate== | ==Crystal structure of Human NMPRTase complexed with 5'-phosphoribosyl-1'-pyrophosphate== | ||
<StructureSection load='2e5c' size='340' side='right' caption='[[2e5c]], [[Resolution|resolution]] 2.20Å' scene=''> | <StructureSection load='2e5c' size='340' side='right'caption='[[2e5c]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2e5c]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2e5c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E5C FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PRP:ALPHA-PHOSPHORIBOSYLPYROPHOSPHORIC+ACID'>PRP</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e5c OCA], [https://pdbe.org/2e5c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e5c RCSB], [https://www.ebi.ac.uk/pdbsum/2e5c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e5c ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity). | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
*[[Phosphoribosyltransferase|Phosphoribosyltransferase]] | *[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Kobayashi | [[Category: Kobayashi Y]] | ||
[[Category: Nakamura | [[Category: Nakamura S]] | ||
[[Category: Ohkubo | [[Category: Ohkubo T]] | ||
[[Category: Takahashi | [[Category: Takahashi R]] | ||