2e43: Difference between revisions

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-[[Image:2e43.jpg|left|200px]]
- {{Structure
+==Crystal structure of C/EBPbeta Bzip homodimer K269A mutant bound to A High Affinity DNA fragment==
-|PDB= 2e43 |SIZE=350|CAPTION= <scene name='initialview01'>2e43</scene>, resolution 2.10&Aring;
+<StructureSection load='2e43' size='340' side='right'caption='[[2e43]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND=
+<table><tr><td colspan='2'>[[2e43]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E43 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E43 FirstGlance]. <br>
-|ACTIVITY=
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-|GENE= CEBPB, TCF5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e43 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e43 OCA], [https://pdbe.org/2e43 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e43 RCSB], [https://www.ebi.ac.uk/pdbsum/2e43 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e43 ProSAT], [https://www.topsan.org/Proteins/RSGI/2e43 TOPSAN]</span></td></tr>
-}}
+</table>
+== Function ==
-'''Crystal structure of C/EBPbeta Bzip homodimer K269A mutant bound to A High Affinity DNA fragment'''
+[https://www.uniprot.org/uniprot/CEBPB_HUMAN CEBPB_HUMAN] Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses. Specifically binds to an IL-1 response element in the IL-6 gene. NF-IL6 also binds to regulatory regions of several acute-phase and cytokines genes. It probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Functions in brown adipose tissue (BAT) differentiation (By similarity). Regulates the transcriptional induction of peroxisome proliferator-activated receptor gamma (PPARG).<ref>PMID:20829347</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
-==About this Structure==
+Check<jmol>
-E43 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E43 OCA].
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e4/2e43_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2e43 ConSurf].
+<div style="clear:both"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Protein complex]]
+[[Category: Large Structures]]
-[[Category: Hamada, K.]]
+[[Category: Hamada K]]
-[[Category: Inoue-Bungo, T.]]
+[[Category: Inoue-Bungo T]]
-[[Category: Ogata, K.]]
+[[Category: Ogata K]]
-[[Category: Sato, K.]]
+[[Category: Sato K]]
-[[Category: Shiina, M.]]
+[[Category: Shiina M]]
-[[Category: Tahirov, T H.]]
+[[Category: Tahirov TH]]
-[[Category: protein-dna complex]]
-[[Category: transcription/dna]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:35:05 2008''