2e43: Difference between revisions

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New page: left|200px<br /><applet load="2e43" size="450" color="white" frame="true" align="right" spinBox="true" caption="2e43, resolution 2.10Å" /> '''Crystal structure of...
 
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[[Image:2e43.jpg|left|200px]]<br /><applet load="2e43" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2e43, resolution 2.10&Aring;" />
'''Crystal structure of C/EBPbeta Bzip homodimer K269A mutant bound to A High Affinity DNA fragment'''<br />


==About this Structure==
==Crystal structure of C/EBPbeta Bzip homodimer K269A mutant bound to A High Affinity DNA fragment==
2E43 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2E43 OCA].  
<StructureSection load='2e43' size='340' side='right'caption='[[2e43]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2e43]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E43 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E43 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e43 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e43 OCA], [https://pdbe.org/2e43 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e43 RCSB], [https://www.ebi.ac.uk/pdbsum/2e43 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e43 ProSAT], [https://www.topsan.org/Proteins/RSGI/2e43 TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CEBPB_HUMAN CEBPB_HUMAN] Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses. Specifically binds to an IL-1 response element in the IL-6 gene. NF-IL6 also binds to regulatory regions of several acute-phase and cytokines genes. It probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Functions in brown adipose tissue (BAT) differentiation (By similarity). Regulates the transcriptional induction of peroxisome proliferator-activated receptor gamma (PPARG).<ref>PMID:20829347</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e4/2e43_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2e43 ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Large Structures]]
[[Category: Hamada, K.]]
[[Category: Hamada K]]
[[Category: Inoue-Bungo, T.]]
[[Category: Inoue-Bungo T]]
[[Category: Ogata, K.]]
[[Category: Ogata K]]
[[Category: Sato, K.]]
[[Category: Sato K]]
[[Category: Shiina, M.]]
[[Category: Shiina M]]
[[Category: Tahirov, T.H.]]
[[Category: Tahirov TH]]
[[Category: protein-dna complex]]
[[Category: transcription/dna]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Dec 19 11:11:55 2007''

Latest revision as of 11:34, 25 October 2023

Crystal structure of C/EBPbeta Bzip homodimer K269A mutant bound to A High Affinity DNA fragmentCrystal structure of C/EBPbeta Bzip homodimer K269A mutant bound to A High Affinity DNA fragment

Structural highlights

2e43 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.1Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

CEBPB_HUMAN Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses. Specifically binds to an IL-1 response element in the IL-6 gene. NF-IL6 also binds to regulatory regions of several acute-phase and cytokines genes. It probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Functions in brown adipose tissue (BAT) differentiation (By similarity). Regulates the transcriptional induction of peroxisome proliferator-activated receptor gamma (PPARG).[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Park SH, Choi HJ, Yang H, Do KH, Kim J, Lee DW, Moon Y. Endoplasmic reticulum stress-activated C/EBP homologous protein enhances nuclear factor-kappaB signals via repression of peroxisome proliferator-activated receptor gamma. J Biol Chem. 2010 Nov 12;285(46):35330-9. doi: 10.1074/jbc.M110.136259. Epub 2010, Sep 9. PMID:20829347 doi:10.1074/jbc.M110.136259

2e43, resolution 2.10Å

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