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==Crystal Structure of Dihydropteroate Synthase from Thermus thermophilus HB8 in Complex with 4-aminobenzoate==
==Crystal Structure of Dihydropteroate Synthase from Thermus thermophilus HB8 in Complex with 4-aminobenzoate==
<StructureSection load='2dza' size='340' side='right' caption='[[2dza]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='2dza' size='340' side='right'caption='[[2dza]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2dza]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thet8 Thet8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DZA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DZA FirstGlance]. <br>
<table><tr><td colspan='2'>[[2dza]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DZA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DZA FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PAB:4-AMINOBENZOIC+ACID'>PAB</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2dqw|2dqw]], [[2dzb|2dzb]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PAB:4-AMINOBENZOIC+ACID'>PAB</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FolP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=300852 THET8])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dza OCA], [https://pdbe.org/2dza PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dza RCSB], [https://www.ebi.ac.uk/pdbsum/2dza PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dza ProSAT], [https://www.topsan.org/Proteins/RSGI/2dza TOPSAN]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydropteroate_synthase Dihydropteroate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.15 2.5.1.15] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dza OCA], [http://pdbe.org/2dza PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2dza RCSB], [http://www.ebi.ac.uk/pdbsum/2dza PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2dza ProSAT], [http://www.topsan.org/Proteins/RSGI/2dza TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/Q5SLV2_THET8 Q5SLV2_THET8]] DHPS catalyzes the formation of the immediate precursor of folic acid.[RuleBase:RU361205]  
[https://www.uniprot.org/uniprot/Q5SLV2_THET8 Q5SLV2_THET8] DHPS catalyzes the formation of the immediate precursor of folic acid.[RuleBase:RU361205]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
*[[Dihydropteroate synthase|Dihydropteroate synthase]]
*[[Dihydropteroate synthase 3D structures|Dihydropteroate synthase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Dihydropteroate synthase]]
[[Category: Large Structures]]
[[Category: Thet8]]
[[Category: Thermus thermophilus HB8]]
[[Category: Bagautdinov, B]]
[[Category: Bagautdinov B]]
[[Category: Kunishima, N]]
[[Category: Kunishima N]]
[[Category: Structural genomic]]
[[Category: 4-aminobenzoate]]
[[Category: Dimer]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Rsgi]]
[[Category: Transferase]]

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