2dqt: Difference between revisions

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==High resolution crystal structure of the complex of the hydrolytic antibody Fab 6D9 and a transition-state analog==
==High resolution crystal structure of the complex of the hydrolytic antibody Fab 6D9 and a transition-state analog==
<StructureSection load='2dqt' size='340' side='right' caption='[[2dqt]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='2dqt' size='340' side='right'caption='[[2dqt]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2dqt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1hyx 1hyx]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DQT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DQT FirstGlance]. <br>
<table><tr><td colspan='2'>[[2dqt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1hyx 1hyx]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DQT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DQT FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CPD:[1-(3-DIMETHYLAMINO-PROPYL)-3-ETHYL-UREIDO]-[4-(2,2,2-TRIFLUORO-ACETYLAMINO)-BENZYL]PHOSPHINIC+ACID-2-(2,2-DIHYDRO-ACETYLAMINO)-3-HYDROXY-1-(4-NITROPHENYL)-PROPYL+ESTER'>CPD</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2dqu|2dqu]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CPD:[1-(3-DIMETHYLAMINO-PROPYL)-3-ETHYL-UREIDO]-[4-(2,2,2-TRIFLUORO-ACETYLAMINO)-BENZYL]PHOSPHINIC+ACID-2-(2,2-DIHYDRO-ACETYLAMINO)-3-HYDROXY-1-(4-NITROPHENYL)-PROPYL+ESTER'>CPD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dqt OCA], [http://pdbe.org/2dqt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2dqt RCSB], [http://www.ebi.ac.uk/pdbsum/2dqt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2dqt ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dqt OCA], [https://pdbe.org/2dqt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dqt RCSB], [https://www.ebi.ac.uk/pdbsum/2dqt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dqt ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A2NHM3_MOUSE A2NHM3_MOUSE]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dq/2dqt_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dq/2dqt_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
*[[3D structures of monoclonal antibody|3D structures of monoclonal antibody]]
*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Lk3 transgenic mice]]
[[Category: Large Structures]]
[[Category: Fujii, I]]
[[Category: Mus musculus]]
[[Category: Ito, N]]
[[Category: Fujii I]]
[[Category: Kristensen, O]]
[[Category: Ito N]]
[[Category: Morikawa, K]]
[[Category: Kristensen O]]
[[Category: Tanaka, F]]
[[Category: Morikawa K]]
[[Category: Vassylyev, D G]]
[[Category: Tanaka F]]
[[Category: Catalytic antibody]]
[[Category: Vassylyev DG]]
[[Category: Ester hydrolysis]]
[[Category: Esterolytic]]
[[Category: Fab]]
[[Category: Immune system]]
[[Category: Immunoglobulin]]

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