2dpx: Difference between revisions
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<StructureSection load='2dpx' size='340' side='right'caption='[[2dpx]], [[Resolution|resolution]] 1.80Å' scene=''> | <StructureSection load='2dpx' size='340' side='right'caption='[[2dpx]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2dpx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2dpx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DPX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DPX FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dpx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dpx OCA], [https://pdbe.org/2dpx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dpx RCSB], [https://www.ebi.ac.uk/pdbsum/2dpx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dpx ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dpx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dpx OCA], [https://pdbe.org/2dpx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dpx RCSB], [https://www.ebi.ac.uk/pdbsum/2dpx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dpx ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/RAD_HUMAN RAD_HUMAN] May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D.<ref>PMID:18056528</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Hakoshima T]] | |||
[[Category: Hakoshima | [[Category: Kitano K]] | ||
[[Category: Kitano | [[Category: Sakurai S]] | ||
[[Category: Sakurai | [[Category: Yanuar A]] | ||
[[Category: Yanuar | |||