2df5: Difference between revisions

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-[[Image:2df5.jpg|left|200px]]<br /><applet load="2df5" size="350" color="white" frame="true" align="right" spinBox="true"
-caption="2df5, resolution 2.30&Aring;" />
-'''Crystal Structure of Pf-PCP(1-204)-C'''<br />
-==Overview==
+==Crystal Structure of Pf-PCP(1-204)-C==
-Certain sequences, known as chameleon sequences, take both alpha- and, beta-conformations in natural proteins. We demonstrate that a wild, chameleon sequence fused to the C-terminal alpha-helix or beta-sheet in, foreign stable proteins from hyperthermophiles forms the same conformation, as the host secondary structure. However, no secondary structural, formation is observed when the sequence is attached to the outside of the, secondary structure. These results indicate that this sequence inherently, possesses an ability to make either alpha- or beta-conformation, depending, on the sequentially neighboring secondary structure if little other, nonlocal interaction occurs. Thus, chameleon sequences take on a satellite, state through contagion by the power of a secondary structure. We propose, this "conformational contagion" as a new nonlocal determinant factor in, protein structure and misfolding related to protein conformational, diseases. Proteins 2007. (c) 2007 Wiley-Liss, Inc.
+<StructureSection load='2df5' size='340' side='right'caption='[[2df5]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2df5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DF5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DF5 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2df5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2df5 OCA], [https://pdbe.org/2df5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2df5 RCSB], [https://www.ebi.ac.uk/pdbsum/2df5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2df5 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PCP_PYRFU PCP_PYRFU] Removes 5-oxoproline from various penultimate amino acid residues except L-proline.[HAMAP-Rule:MF_00417]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/df/2df5_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2df5 ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Certain sequences, known as chameleon sequences, take both alpha- and beta-conformations in natural proteins. We demonstrate that a wild chameleon sequence fused to the C-terminal alpha-helix or beta-sheet in foreign stable proteins from hyperthermophiles forms the same conformation as the host secondary structure. However, no secondary structural formation is observed when the sequence is attached to the outside of the secondary structure. These results indicate that this sequence inherently possesses an ability to make either alpha- or beta-conformation, depending on the sequentially neighboring secondary structure if little other nonlocal interaction occurs. Thus, chameleon sequences take on a satellite state through contagion by the power of a secondary structure. We propose this "conformational contagion" as a new nonlocal determinant factor in protein structure and misfolding related to protein conformational diseases.
-==About this Structure==
+Conformational contagion in a protein: structural properties of a chameleon sequence.,Takano K, Katagiri Y, Mukaiyama A, Chon H, Matsumura H, Koga Y, Kanaya S Proteins. 2007 Aug 15;68(3):617-25. PMID:17510955<ref>PMID:17510955</ref>
-DF5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Active as [http://en.wikipedia.org/wiki/Pyroglutamyl-peptidase_I Pyroglutamyl-peptidase I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.3 3.4.19.3] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DF5 OCA].
-==Reference==
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-Conformational contagion in a protein: Structural properties of a chameleon sequence., Takano K, Katagiri Y, Mukaiyama A, Chon H, Matsumura H, Koga Y, Kanaya S, Proteins. 2007 May 17;68(3):617-625. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17510955 17510955]
+</div>
+<div class="pdbe-citations 2df5" style="background-color:#fffaf0;"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Pyrococcus furiosus]]
-[[Category: Pyroglutamyl-peptidase I]]
+[[Category: Chon H]]
-[[Category: Single protein]]
+[[Category: Kanaya S]]
-[[Category: Chon, H.]]
+[[Category: Katagiri Y]]
-[[Category: Kanaya, S.]]
+[[Category: Koga Y]]
-[[Category: Katagiri, Y.]]
+[[Category: Matsumura H]]
-[[Category: Koga, Y.]]
+[[Category: Takano K]]
-[[Category: Matsumura, H.]]
-[[Category: Takano, K.]]
-[[Category: chameleon sequence]]
-[[Category: hydrolase]]
-[[Category: pyrococcus furiosus]]
-[[Category: pyrrolidone carboxyl peptidase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 11:17:40 2008''