2d6k: Difference between revisions

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==Crystal structure of mouse galectin-9 N-terminal CRD (crystal form 1)==
==Crystal structure of mouse galectin-9 N-terminal CRD (crystal form 1)==
<StructureSection load='2d6k' size='340' side='right' caption='[[2d6k]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='2d6k' size='340' side='right'caption='[[2d6k]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2d6k]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D6K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2D6K FirstGlance]. <br>
<table><tr><td colspan='2'>[[2d6k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D6K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2D6K FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2d6l|2d6l]], [[2d6m|2d6m]], [[2d6n|2d6n]], [[2d6o|2d6o]], [[2d6p|2d6p]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2d6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d6k OCA], [http://pdbe.org/2d6k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2d6k RCSB], [http://www.ebi.ac.uk/pdbsum/2d6k PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2d6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d6k OCA], [https://pdbe.org/2d6k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2d6k RCSB], [https://www.ebi.ac.uk/pdbsum/2d6k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2d6k ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/LEG9_MOUSE LEG9_MOUSE]] Binds galactosides. May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. Is a ligand for HAVCR2/TIM3. Induces T-helper type 1 lymphocyte (Th1) death (By similarity).  
[https://www.uniprot.org/uniprot/LEG9_MOUSE LEG9_MOUSE] Binds galactosides. May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. Is a ligand for HAVCR2/TIM3. Induces T-helper type 1 lymphocyte (Th1) death (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d6/2d6k_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d6/2d6k_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2d6k ConSurf].
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<div style="clear:both"></div>
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==See Also==
==See Also==
*[[Galectin|Galectin]]
*[[Galectin 3D structures|Galectin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Lk3 transgenic mice]]
[[Category: Large Structures]]
[[Category: Kato, R]]
[[Category: Mus musculus]]
[[Category: Murata, T]]
[[Category: Kato R]]
[[Category: Nagae, M]]
[[Category: Murata T]]
[[Category: Nakamura, T]]
[[Category: Nagae M]]
[[Category: Nishi, N]]
[[Category: Nakamura T]]
[[Category: Wakatsuki, S]]
[[Category: Nishi N]]
[[Category: Beta sandwich]]
[[Category: Wakatsuki S]]
[[Category: Carbohydrate binding protein]]
[[Category: Galectin]]
[[Category: Sugar binding protein]]

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