2d07: Difference between revisions

<table><tr><td colspan='2'>[[2d07]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D07 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2D07 FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2d07 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d07 OCA], [http://pdbe.org/2d07 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2d07 RCSB], [http://www.ebi.ac.uk/pdbsum/2d07 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2d07 ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/TDG_HUMAN TDG_HUMAN]] In the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. This enzyme corrects G/T mispairs to G/C pairs. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, it can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. It can also remove uracil and 5-bromouracil from mispairs with guanine. [[http://www.uniprot.org/uniprot/SUMO2_HUMAN SUMO2_HUMAN]] Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.<ref>PMID:9556629</ref> <ref>PMID:18538659</ref> <ref>PMID:18408734</ref> 

[[Category: Human]]

[[Category: Baba, D]]

[[Category: Hanaoka, F]]

[[Category: Hiroaki, H]]

[[Category: Jee, J G]]

[[Category: Maita, N]]

[[Category: Saitoh, H]]

[[Category: Shirakawa, M]]

[[Category: Sugasawa, K]]

[[Category: Tochio, H]]

[[Category: Uchimura, Y]]

[[Category: Hydrolase]]