1wne: Difference between revisions

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<StructureSection load='1wne' size='340' side='right'caption='[[1wne]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
<StructureSection load='1wne' size='340' side='right'caption='[[1wne]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1wne]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Foot-and-mouth_disease_virus_c-s8c1 Foot-and-mouth disease virus c-s8c1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WNE OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1WNE FirstGlance]. <br>
<table><tr><td colspan='2'>[[1wne]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Foot-and-mouth_disease_virus_C-S8c1 Foot-and-mouth disease virus C-S8c1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WNE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WNE FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1u09|1u09]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Viruses ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=244367 Foot-and-mouth disease virus C-S8c1])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wne OCA], [https://pdbe.org/1wne PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wne RCSB], [https://www.ebi.ac.uk/pdbsum/1wne PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wne ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1wne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wne OCA], [http://pdbe.org/1wne PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wne RCSB], [http://www.ebi.ac.uk/pdbsum/1wne PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1wne ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/Q9QCE4_9PICO Q9QCE4_9PICO]] Protein 3C is a cysteine protease that generates mature viral proteins from the precursor polyprotein. In addition to its proteolytic activity, it binds to viral RNA, and thus influences viral genome replication. RNA and substrate bind co-operatively to the protease (By similarity).[SAAS:SAAS000199_004_042266]  RNA-directed RNA polymerase 3D-POL replicates genomic and antigenomic RNA by recognizing replications specific signals (By similarity).[SAAS:SAAS000199_004_010047]  
[https://www.uniprot.org/uniprot/Q9QCE4_9PICO Q9QCE4_9PICO] Protein 3C is a cysteine protease that generates mature viral proteins from the precursor polyprotein. In addition to its proteolytic activity, it binds to viral RNA, and thus influences viral genome replication. RNA and substrate bind co-operatively to the protease (By similarity).[SAAS:SAAS000199_004_042266]  RNA-directed RNA polymerase 3D-POL replicates genomic and antigenomic RNA by recognizing replications specific signals (By similarity).[SAAS:SAAS000199_004_010047]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Foot-and-mouth disease virus c-s8c1]]
[[Category: Foot-and-mouth disease virus C-S8c1]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: RNA-directed RNA polymerase]]
[[Category: Arias A]]
[[Category: Arias, A]]
[[Category: Domingo E]]
[[Category: Domingo, E]]
[[Category: Escarmis C]]
[[Category: Escarmis, C]]
[[Category: Ferrer-Orta C]]
[[Category: Ferrer-Orta, C]]
[[Category: Perez-Luque R]]
[[Category: Perez-Luque, R]]
[[Category: Verdaguer N]]
[[Category: Verdaguer, N]]
[[Category: Foot and mouth disease virus]]
[[Category: Protein-dna complex]]
[[Category: Rna-dependent rna polymerase]]
[[Category: Transferase-rna complex]]

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