1v3d: Difference between revisions

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-{{Seed}}
-[[Image:1v3d.png|left|200px]]
-<!--
+==Structure of the hemagglutinin-neuraminidase from human parainfluenza virus type III: complex with NEU5AC2EN==
-The line below this paragraph, containing "STRUCTURE_1v3d", creates the "Structure Box" on the page.
+<StructureSection load='1v3d' size='340' side='right'caption='[[1v3d]], [[Resolution|resolution]] 2.28&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1v3d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_respirovirus_3 Human respirovirus 3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V3D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1V3D FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.28&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DAN:2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC+ACID'>DAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-{{STRUCTURE_1v3d|  PDB=1v3d  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1v3d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v3d OCA], [https://pdbe.org/1v3d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1v3d RCSB], [https://www.ebi.ac.uk/pdbsum/1v3d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1v3d ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q6WJ03_9MONO Q6WJ03_9MONO] Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion.[ARBA:ARBA00025476]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v3/1v3d_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1v3d ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The three-dimensional structure of the haemagglutinin-neuraminidase (HN) from a human parainfluenza virus is described at ca 2.0 A resolution, both in native form and in complex with three substrate analogues. In support of earlier work on the structure of the homologous protein from the avian pathogen Newcastle disease virus (NDV), we observe a dimer of beta-propellers and find no evidence for spatially separated sites performing the receptor-binding and neuraminidase functions of the protein. As with the NDV HN, the active site of the HN of parainfluenza viruses is structurally flexible, suggesting that it may be able to switch between a receptor-binding state and a catalytic state. However, in contrast to the NDV structures, we observe no ligand-induced structural changes that extend beyond the active site and modify the dimer interface.
-===Structure of the hemagglutinin-neuraminidase from human parainfluenza virus type III: complex with NEU5AC2EN===
+Structure of the haemagglutinin-neuraminidase from human parainfluenza virus type III.,Lawrence MC, Borg NA, Streltsov VA, Pilling PA, Epa VC, Varghese JN, McKimm-Breschkin JL, Colman PM J Mol Biol. 2004 Jan 30;335(5):1343-57. PMID:14729348<ref>PMID:14729348</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 1v3d" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_14729348}}, adds the Publication Abstract to the page
+*[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 14729348 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_14729348}}
+__TOC__
+</StructureSection>
-==About this Structure==
+[[Category: Human respirovirus 3]]
-V3D is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Human_parainfluenza_virus_3 Human parainfluenza virus 3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V3D OCA].
+[[Category: Large Structures]]
+[[Category: Borg NA]]
-==Reference==
+[[Category: Colman PM]]
-<ref group="xtra">PMID:14729348</ref><references group="xtra"/>
+[[Category: Epa VC]]
-[[Category: Exo-alpha-sialidase]]
+[[Category: Lawrence MC]]
-[[Category: Human parainfluenza virus 3]]
+[[Category: McKimm-Breschkin JL]]
-[[Category: Borg, N A.]]
+[[Category: Pilling PA]]
-[[Category: Colman, P M.]]
+[[Category: Streltsov VA]]
-[[Category: Epa, V C.]]
+[[Category: Varghese JN]]
-[[Category: Lawrence, M C.]]
-[[Category: McKimm-Breschkin, J L.]]
-[[Category: Pilling, P A.]]
-[[Category: Streltsov, V A.]]
-[[Category: Varghese, J N.]]
-[[Category: Hexagonal]]
-[[Category: Native+neu5ac2en]]
-[[Category: Piv3 hn]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 20:21:52 2009''