1ui9: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older edit
No edit summary
No edit summary
 
(14 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:1ui9.jpg|left|200px]]<br /><applet load="1ui9" size="350" color="white" frame="true" align="right" spinBox="true"
caption="1ui9, resolution 1.65&Aring;" />
'''Crystal analysis of chorismate mutase from thermus thermophilus'''<br />


==About this Structure==
==Crystal analysis of chorismate mutase from thermus thermophilus==
1UI9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus] with <scene name='pdbligand=MES:'>MES</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Chorismate_mutase Chorismate mutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.99.5 5.4.99.5] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UI9 OCA].  
<StructureSection load='1ui9' size='340' side='right'caption='[[1ui9]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
[[Category: Chorismate mutase]]
== Structural highlights ==
[[Category: Single protein]]
<table><tr><td colspan='2'>[[1ui9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. The April 2010 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Concanavalin A and Circular Permutation''  by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2010_4 10.2210/rcsb_pdb/mom_2010_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UI9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UI9 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ui9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ui9 OCA], [https://pdbe.org/1ui9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ui9 RCSB], [https://www.ebi.ac.uk/pdbsum/1ui9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ui9 ProSAT], [https://www.topsan.org/Proteins/RSGI/1ui9 TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/AROH_THETH AROH_THETH] Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis.<ref>PMID:14727008</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ui/1ui9_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ui9 ConSurf].
<div style="clear:both"></div>
 
==See Also==
*[[3D structures of chorismate mutase|3D structures of chorismate mutase]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Concanavalin A and Circular Permutation]]
[[Category: Large Structures]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: Thermus thermophilus]]
[[Category: Thermus thermophilus]]
[[Category: Inagaki, E.]]
[[Category: Inagaki E]]
[[Category: Kuramitsu, S.]]
[[Category: Kuramitsu S]]
[[Category: Miyano, M.]]
[[Category: Miyano M]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Tahirov TH]]
[[Category: Tahirov, T H.]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S.]]
[[Category: GOL]]
[[Category: MES]]
[[Category: chorismate mutase]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rsgi]]
[[Category: shikimate pathway]]
[[Category: structural genomics]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:24:46 2008''

Latest revision as of 10:38, 25 October 2023

Crystal analysis of chorismate mutase from thermus thermophilusCrystal analysis of chorismate mutase from thermus thermophilus

Structural highlights

1ui9 is a 1 chain structure with sequence from Thermus thermophilus. The April 2010 RCSB PDB Molecule of the Month feature on Concanavalin A and Circular Permutation by David Goodsell is 10.2210/rcsb_pdb/mom_2010_4. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.65Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

AROH_THETH Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Helmstaedt K, Heinrich G, Merkl R, Braus GH. Chorismate mutase of Thermus thermophilus is a monofunctional AroH class enzyme inhibited by tyrosine. Arch Microbiol. 2004 Mar;181(3):195-203. Epub 2004 Jan 15. PMID:14727008 doi:http://dx.doi.org/10.1007/s00203-003-0639-z

1ui9, resolution 1.65Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=1ui9&oldid=3921761"