1ue7: Difference between revisions

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-{{Seed}}
-[[Image:1ue7.png|left|200px]]
-<!--
+==Crystal structure of the single-stranded dna-binding protein from mycobacterium tuberculosis==
-The line below this paragraph, containing "STRUCTURE_1ue7", creates the "Structure Box" on the page.
+<StructureSection load='1ue7' size='340' side='right'caption='[[1ue7]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1ue7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UE7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UE7 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ue7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ue7 OCA], [https://pdbe.org/1ue7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ue7 RCSB], [https://www.ebi.ac.uk/pdbsum/1ue7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ue7 ProSAT], [https://www.topsan.org/Proteins/TBSGC/1ue7 TOPSAN]</span></td></tr>
-{{STRUCTURE_1ue7|  PDB=1ue7  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/SSB_MYCTU SSB_MYCTU] This protein is essential for replication of the chromosome. It is also involved in DNA recombination and repair (By similarity).
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ue/1ue7_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ue7 ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Single-stranded DNA-binding protein (SSB) is an essential protein necessary for the functioning of the DNA replication, repair and recombination machineries. Here we report the structure of the DNA-binding domain of Mycobacterium tuberculosis SSB (MtuSSB) in four different crystals distributed in two forms. The structure of one of the forms was solved by a combination of isomorphous replacement and anomalous scattering. This structure was used to determine the structure of the other form by molecular replacement. The polypeptide chain in the structure exhibits the oligonucleotide binding fold. The globular core of the molecule in different subunits in the two forms and those in Escherichia coli SSB (EcoSSB) and human mitochondrial SSB (HMtSSB) have similar structure, although the three loops exhibit considerable structural variation. However, the tetrameric MtuSSB has an as yet unobserved quaternary association. This quaternary structure with a unique dimeric interface lends the oligomeric protein greater stability, which may be of significance to the functioning of the protein under conditions of stress. Also, as a result of the variation in the quaternary structure the path adopted by the DNA to wrap around MtuSSB is expected to be different from that of EcoSSB.
-===Crystal structure of the single-stranded dna-binding protein from mycobacterium tuberculosis===
+Structure of Mycobacterium tuberculosis single-stranded DNA-binding protein. Variability in quaternary structure and its implications.,Saikrishnan K, Jeyakanthan J, Venkatesh J, Acharya N, Sekar K, Varshney U, Vijayan M J Mol Biol. 2003 Aug 8;331(2):385-93. PMID:12888346<ref>PMID:12888346</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 1ue7" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_12888346}}, adds the Publication Abstract to the page
+*[[Single-stranded DNA-binding protein 3D structures|Single-stranded DNA-binding protein 3D structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 12888346 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_12888346}}
+__TOC__
+</StructureSection>
-==About this Structure==
+[[Category: Large Structures]]
-UE7 is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UE7 OCA].
-==Reference==
-<ref group="xtra">PMID:12888346</ref><ref group="xtra">PMID:11807266</ref><references group="xtra"/>
 [[Category: Mycobacterium tuberculosis]]
-[[Category: Acharya, N.]]
+[[Category: Acharya N]]
-[[Category: Jeyakanthan, J.]]
+[[Category: Jeyakanthan J]]
-[[Category: Saikrishnan, K.]]
+[[Category: Saikrishnan K]]
-[[Category: Sekar, K.]]
+[[Category: Sekar K]]
-[[Category: TBSGC, TB Structural Genomics Consortium.]]
+[[Category: Varshney U]]
-[[Category: Varshney, U.]]
+[[Category: Venkatesh J]]
-[[Category: Venkatesh, J.]]
+[[Category: Vijayan M]]
-[[Category: Vijayan, M.]]
-[[Category: Dna-binding protein]]
-[[Category: Oligonucleotide binding fold]]
-[[Category: Protein structure initiative]]
-[[Category: Psi]]
-[[Category: Structural genomic]]
-[[Category: Tb structural genomics consortium]]
-[[Category: Tbsgc]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 18:05:04 2009''