1tr7: Difference between revisions
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==FimH adhesin receptor binding domain from uropathogenic E. coli== | ==FimH adhesin receptor binding domain from uropathogenic E. coli== | ||
<StructureSection load='1tr7' size='340' side='right' caption='[[1tr7]], [[Resolution|resolution]] 2.10Å' scene=''> | <StructureSection load='1tr7' size='340' side='right'caption='[[1tr7]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1tr7]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[1tr7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TR7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TR7 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=DEG:BUTYL+ALPHA-D-MANNOPYRANOSIDE'>DEG</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=DEG:BUTYL+ALPHA-D-MANNOPYRANOSIDE'>DEG</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tr7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tr7 OCA], [https://pdbe.org/1tr7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tr7 RCSB], [https://www.ebi.ac.uk/pdbsum/1tr7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tr7 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/FIMH_ECOLI FIMH_ECOLI] Involved in regulation of length and mediation of adhesion of type 1 fimbriae (but not necessary for the production of fimbriae). Adhesin responsible for the binding to D-mannose. It is laterally positioned at intervals in the structure of the type 1 fimbriae. In order to integrate FimH in the fimbriae FimF and FimG are needed. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tr/1tr7_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tr/1tr7_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tr7 ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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==See Also== | ==See Also== | ||
*[[Adhesin 3D structures|Adhesin 3D structures]] | |||
*[[Urease|Urease]] | *[[Urease|Urease]] | ||
== References == | == References == | ||
| Line 35: | Line 37: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Escherichia coli]] | ||
[[Category: Berglund | [[Category: Large Structures]] | ||
[[Category: Bouckaert | [[Category: Berglund J]] | ||
[[Category: Choudhury | [[Category: Bouckaert J]] | ||
[[Category: Cools | [[Category: Choudhury D]] | ||
[[Category: Genst | [[Category: Cools L]] | ||
[[Category: Greve | [[Category: De Genst E]] | ||
[[Category: Hultgren | [[Category: De Greve H]] | ||
[[Category: Hung | [[Category: Hultgren SJ]] | ||
[[Category: Klemm | [[Category: Hung CS]] | ||
[[Category: Knight | [[Category: Klemm P]] | ||
[[Category: Langermann | [[Category: Knight SD]] | ||
[[Category: Oscarson | [[Category: Langermann S]] | ||
[[Category: Pinkner | [[Category: Oscarson S]] | ||
[[Category: Schembri | [[Category: Pinkner J]] | ||
[[Category: Slattegard | [[Category: Schembri M]] | ||
[[Category: Wuhrer | [[Category: Slattegard R]] | ||
[[Category: Wyns | [[Category: Wuhrer M]] | ||
[[Category: Zavialov | [[Category: Wyns L]] | ||
[[Category: Zavialov A]] | |||