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==Understanding protein lids: Structural analysis of active hinge mutants in triosephosphate isomerase==
==Understanding protein lids: Structural analysis of active hinge mutants in triosephosphate isomerase==
<StructureSection load='1ssg' size='340' side='right' caption='[[1ssg]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
<StructureSection load='1ssg' size='340' side='right'caption='[[1ssg]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1ssg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SSG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SSG FirstGlance]. <br>
<table><tr><td colspan='2'>[[1ssg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SSG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SSG FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PGA:2-PHOSPHOGLYCOLIC+ACID'>PGA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1spq|1spq]], [[1sq7|1sq7]], [[1ssd|1ssd]], [[1su5|1su5]], [[1sw0|1sw0]], [[1sw3|1sw3]], [[1sw7|1sw7]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PGA:2-PHOSPHOGLYCOLIC+ACID'>PGA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TPI1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ssg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ssg OCA], [https://pdbe.org/1ssg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ssg RCSB], [https://www.ebi.ac.uk/pdbsum/1ssg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ssg ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ssg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ssg OCA], [http://pdbe.org/1ssg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ssg RCSB], [http://www.ebi.ac.uk/pdbsum/1ssg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ssg ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TPIS_CHICK TPIS_CHICK]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ss/1ssg_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ss/1ssg_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
*[[Triose Phosphate Isomerase|Triose Phosphate Isomerase]]
*[[Triose phosphate isomerase 3D structures|Triose phosphate isomerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Chick]]
[[Category: Gallus gallus]]
[[Category: Triose-phosphate isomerase]]
[[Category: Large Structures]]
[[Category: Haapalainen, A M]]
[[Category: Haapalainen AM]]
[[Category: Kursula, I]]
[[Category: Kursula I]]
[[Category: Norledge, B V]]
[[Category: Norledge BV]]
[[Category: Salin, M]]
[[Category: Salin M]]
[[Category: Sampson, N S]]
[[Category: Sampson NS]]
[[Category: Sun, J]]
[[Category: Sun J]]
[[Category: Wierenga, R K]]
[[Category: Wierenga RK]]
[[Category: Archae]]
[[Category: Evolution]]
[[Category: Flexible loop-6]]
[[Category: Isomerase]]
[[Category: N-hinge]]
[[Category: Tim]]

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