1np2: Difference between revisions

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-{{Seed}}
-[[Image:1np2.png|left|200px]]
-<!--
+==Crystal structure of thermostable beta-glycosidase from thermophilic eubacterium Thermus nonproteolyticus HG102==
-The line below this paragraph, containing "STRUCTURE_1np2", creates the "Structure Box" on the page.
+<StructureSection load='1np2' size='340' side='right'caption='[[1np2]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1np2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_nonproteolyticus Thermus nonproteolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NP2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NP2 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1np2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1np2 OCA], [https://pdbe.org/1np2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1np2 RCSB], [https://www.ebi.ac.uk/pdbsum/1np2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1np2 ProSAT]</span></td></tr>
-{{STRUCTURE_1np2|  PDB=1np2  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q9L794_9DEIN Q9L794_9DEIN]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/np/1np2_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1np2 ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The three-dimensional structure of a thermostable beta-glycosidase (Gly(Tn)) from the thermophilic eubacterium Thermus nonproteolyticus HG102 was determined at a resolution of 2.4 A. The core of the structure adopts the (betaalpha)(8) barrel fold. The sequence alignments and the positions of the two Glu residues in the active center indicate that Gly(Tn) belongs to the glycosyl hydrolases of retaining family 1. We have analyzed the structural features of Gly(Tn) related to the thermostability and compared its structure with those of other mesophilic glycosidases from plants, eubacteria, and hyperthermophilic enzymes from archaea. Several possible features contributing to the thermostability of Gly(Tn) were elucidated.
-===Crystal structure of thermostable beta-glycosidase from thermophilic eubacterium Thermus nonproteolyticus HG102===
+Structural basis for thermostability of beta-glycosidase from the thermophilic eubacterium Thermus nonproteolyticus HG102.,Wang X, He X, Yang S, An X, Chang W, Liang D J Bacteriol. 2003 Jul;185(14):4248-55. PMID:12837801<ref>PMID:12837801</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-<!--
+</div>
-The line below this paragraph, {{ABSTRACT_PUBMED_12837801}}, adds the Publication Abstract to the page
+<div class="pdbe-citations 1np2" style="background-color:#fffaf0;"></div>
-(as it appears on PubMed at http://www.pubmed.gov), where 12837801 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_12837801}}
+__TOC__
+</StructureSection>
-==About this Structure==
+[[Category: Large Structures]]
-NP2 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Thermus_nonproteolyticus Thermus nonproteolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NP2 OCA].
-==Reference==
-<ref group="xtra">PMID:12837801</ref><references group="xtra"/>
-[[Category: Beta-glucosidase]]
 [[Category: Thermus nonproteolyticus]]
-[[Category: Chang, W R.]]
+[[Category: Chang WR]]
-[[Category: He, X Y.]]
+[[Category: He XY]]
-[[Category: Liang, D C.]]
+[[Category: Liang DC]]
-[[Category: Wang, X Q.]]
+[[Category: Wang XQ]]
-[[Category: Tim barrel]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 05:14:32 2009''