1lv8: Difference between revisions

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==Crystal structure of calf spleen purine nucleoside phosphorylase in a new space group with full trimer in the asymmetric unit==
==Crystal structure of calf spleen purine nucleoside phosphorylase in a new space group with full trimer in the asymmetric unit==
<StructureSection load='1lv8' size='340' side='right' caption='[[1lv8]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='1lv8' size='340' side='right'caption='[[1lv8]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1lv8]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LV8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LV8 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1lv8]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LV8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LV8 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9PP:2,6-DIAMINO-(S)-9-[2-(PHOSPHONOMETHOXY)PROPYL]PURINE'>9PP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1fxu|1fxu]], [[1lvu|1lvu]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9PP:2,6-DIAMINO-(S)-9-[2-(PHOSPHONOMETHOXY)PROPYL]PURINE'>9PP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Purine-nucleoside_phosphorylase Purine-nucleoside phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.1 2.4.2.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lv8 OCA], [https://pdbe.org/1lv8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lv8 RCSB], [https://www.ebi.ac.uk/pdbsum/1lv8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lv8 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lv8 OCA], [http://pdbe.org/1lv8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1lv8 RCSB], [http://www.ebi.ac.uk/pdbsum/1lv8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1lv8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PNPH_BOVIN PNPH_BOVIN]] The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.  
[https://www.uniprot.org/uniprot/PNPH_BOVIN PNPH_BOVIN] The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lv/1lv8_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lv/1lv8_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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</div>
</div>
<div class="pdbe-citations 1lv8" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 1lv8" style="background-color:#fffaf0;"></div>
==See Also==
*[[Purine nucleoside phosphorylase 3D structures|Purine nucleoside phosphorylase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bovin]]
[[Category: Bos taurus]]
[[Category: Purine-nucleoside phosphorylase]]
[[Category: Large Structures]]
[[Category: Bzowska, A]]
[[Category: Bzowska A]]
[[Category: Frank, J]]
[[Category: Frank J]]
[[Category: Holy, A]]
[[Category: Holy A]]
[[Category: Koellner, G]]
[[Category: Koellner G]]
[[Category: Raszewski, G]]
[[Category: Raszewski G]]
[[Category: Steiner, T]]
[[Category: Steiner T]]
[[Category: Stroh, A]]
[[Category: Stroh A]]
[[Category: Wielgus-Kutrowska, B]]
[[Category: Wielgus-Kutrowska B]]
[[Category: 6-diaminopurine multisubstrate analogue inhibitor]]
[[Category: Ne 2]]
[[Category: Pentosyltransferase]]
[[Category: Pnp]]
[[Category: Purie nucleoside phosphorylase]]
[[Category: Transferase]]

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