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[[Image:1j2y.jpg|left|200px]]


{{Structure
==Crystal structure of the type II 3-dehydroquinase==
|PDB= 1j2y |SIZE=350|CAPTION= <scene name='initialview01'>1j2y</scene>, resolution 2.60&Aring;
<StructureSection load='1j2y' size='340' side='right'caption='[[1j2y]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=DQA:1,3,4-TRIHYDROXY-5-OXO-CYCLOHEXANECARBOXYLIC+ACID'>DQA</scene>
<table><tr><td colspan='2'>[[1j2y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J2Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1J2Y FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/3-dehydroquinate_dehydratase 3-dehydroquinate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.10 4.2.1.10] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
|GENE= aroQ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=210 Helicobacter pylori])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DQA:1,3,4-TRIHYDROXY-5-OXO-CYCLOHEXANECARBOXYLIC+ACID'>DQA</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1j2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j2y OCA], [https://pdbe.org/1j2y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1j2y RCSB], [https://www.ebi.ac.uk/pdbsum/1j2y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1j2y ProSAT]</span></td></tr>
|RELATEDENTRY=
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1j2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j2y OCA], [http://www.ebi.ac.uk/pdbsum/1j2y PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1j2y RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/AROQ_HELPY AROQ_HELPY] Catalyzes a trans-dehydration via an enolate intermediate (By similarity).[HAMAP-Rule:MF_00169]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j2/1j2y_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1j2y ConSurf].
<div style="clear:both"></div>


'''Crystal structure of the type II 3-dehydroquinase'''
==See Also==
 
*[[Dehydroquinase 3D structures|Dehydroquinase 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
1J2Y is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J2Y OCA].
 
==Reference==
Crystal structure of the type II 3-dehydroquinase from Helicobacter pylori., Lee BI, Kwak JE, Suh SW, Proteins. 2003 Jun 1;51(4):616-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12784220 12784220]
[[Category: 3-dehydroquinate dehydratase]]
[[Category: Helicobacter pylori]]
[[Category: Helicobacter pylori]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Kwak, J E.]]
[[Category: Kwak JE]]
[[Category: Lee, B I.]]
[[Category: Lee BI]]
[[Category: Suh, S W.]]
[[Category: Suh SW]]
[[Category: 3-dehydroquinase]]
[[Category: lyase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:28:06 2008''

Latest revision as of 10:14, 25 October 2023

Crystal structure of the type II 3-dehydroquinaseCrystal structure of the type II 3-dehydroquinase

Structural highlights

1j2y is a 1 chain structure with sequence from Helicobacter pylori. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.6Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

AROQ_HELPY Catalyzes a trans-dehydration via an enolate intermediate (By similarity).[HAMAP-Rule:MF_00169]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1j2y, resolution 2.60Å

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