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==Inhibitor of HIV protease with unusual binding mode potently inhibiting multi-resistant protease mutants== | ==Inhibitor of HIV protease with unusual binding mode potently inhibiting multi-resistant protease mutants== | ||
<StructureSection load='1izh' size='340' side='right' caption='[[1izh]], [[Resolution|resolution]] 1.90Å' scene=''> | <StructureSection load='1izh' size='340' side='right'caption='[[1izh]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1izh]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[1izh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IZH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IZH FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=Q50:{(1S)-1-BENZYL-4-[3-CARBAMOYL-1-(1-CARBAMOYL-2-PHENYL-ETHYLCARBAMOYL)-(S)-PROPYLCARBAMOYL]-2-OXO-5-PHENYL-PENTYL}-CARBAMIC+ACID+TERT-BUTYL+ESTER'>Q50</scene | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=Q50:{(1S)-1-BENZYL-4-[3-CARBAMOYL-1-(1-CARBAMOYL-2-PHENYL-ETHYLCARBAMOYL)-(S)-PROPYLCARBAMOYL]-2-OXO-5-PHENYL-PENTYL}-CARBAMIC+ACID+TERT-BUTYL+ESTER'>Q50</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1izh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1izh OCA], [https://pdbe.org/1izh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1izh RCSB], [https://www.ebi.ac.uk/pdbsum/1izh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1izh ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/Q90EB9_9HIV1 Q90EB9_9HIV1] | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iz/1izh_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iz/1izh_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1izh ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 1izh" style="background-color:#fffaf0;"></div> | |||
== | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human immunodeficiency virus 1]] | [[Category: Human immunodeficiency virus 1]] | ||
[[Category: Hilgenfeld | [[Category: Large Structures]] | ||
[[Category: Klimkait | [[Category: Hilgenfeld R]] | ||
[[Category: Konvalinka | [[Category: Klimkait T]] | ||
[[Category: Kraeusslich | [[Category: Konvalinka J]] | ||
[[Category: Lepsik | [[Category: Kraeusslich H-G]] | ||
[[Category: Machala | [[Category: Lepsik M]] | ||
[[Category: Mesters | [[Category: Machala L]] | ||
[[Category: Mlcochova | [[Category: Mesters JR]] | ||
[[Category: Prejdova | [[Category: Mlcochova P]] | ||
[[Category: Skalicka | [[Category: Prejdova J]] | ||
[[Category: Soucek | [[Category: Skalicka K]] | ||
[[Category: Sponarova | [[Category: Soucek M]] | ||
[[Category: Stankova | [[Category: Sponarova J]] | ||
[[Category: Strisovsky | [[Category: Stankova M]] | ||
[[Category: Svec | [[Category: Strisovsky K]] | ||
[[Category: Uhlikova | [[Category: Svec M]] | ||
[[Category: Vondrasek | [[Category: Uhlikova T]] | ||
[[Category: Weber | [[Category: Vondrasek J]] | ||
[[Category: Weber J]] | |||