1isn: Difference between revisions

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-{{Seed}}
-[[Image:1isn.png|left|200px]]
-<!--
+==Crystal structure of merlin FERM domain==
-The line below this paragraph, containing "STRUCTURE_1isn", creates the "Structure Box" on the page.
+<StructureSection load='1isn' size='340' side='right'caption='[[1isn]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1isn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ISN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ISN FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1isn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1isn OCA], [https://pdbe.org/1isn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1isn RCSB], [https://www.ebi.ac.uk/pdbsum/1isn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1isn ProSAT]</span></td></tr>
-{{STRUCTURE_1isn|  PDB=1isn  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/MERL_MOUSE MERL_MOUSE] Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex (By similarity). Plays a role in lens development and is required for complete fiber cell terminal differentiation, maintenance of cell polarity and separation of the lens vesicle from the corneal epithelium.<ref>PMID:20181838</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/is/1isn_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1isn ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Neurofibromatosis type 2 (NF2) is a dominantly inherited disease associated with the central nervous system. The NF2 gene product merlin is a tumor suppressor, and its mutation or inactivation causes this disease. We report here the crystal structure of the merlin FERM domain containing a 22-residue alpha-helical segment. The structure reveals that the merlin FERM domain consists of three subdomains displaying notable features of the electrostatic surface potentials, although the overall surface potentials similar to those of ezrin/radixin/moesin (ERM) proteins indicate electrostatic membrane association. The structure also is consistent with inactivation mechanisms caused by the pathogenic mutations associated with NF2.
-===Crystal structure of merlin FERM domain===
+Structural basis for neurofibromatosis type 2. Crystal structure of the merlin FERM domain.,Shimizu T, Seto A, Maita N, Hamada K, Tsukita S, Tsukita S, Hakoshima T J Biol Chem. 2002 Mar 22;277(12):10332-6. Epub 2001 Dec 27. PMID:11756419<ref>PMID:11756419</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 1isn" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_11756419}}, adds the Publication Abstract to the page
+*[[Merlin|Merlin]]
-(as it appears on PubMed at http://www.pubmed.gov), where 11756419 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_11756419}}
+__TOC__
+</StructureSection>
-==About this Structure==
+[[Category: Large Structures]]
-ISN is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ISN OCA].
-==Reference==
-<ref group="xtra">PMID:11756419</ref><references group="xtra"/>
 [[Category: Mus musculus]]
-[[Category: Hakoshima, T.]]
+[[Category: Hakoshima T]]
-[[Category: Hamada, K.]]
+[[Category: Hamada K]]
-[[Category: Maita, N.]]
+[[Category: Maita N]]
-[[Category: Seto, A.]]
+[[Category: Seto A]]
-[[Category: Shimizu, T.]]
+[[Category: Shimizu T]]
-[[Category: Tsukita, S.]]
+[[Category: Tsukita S]]
-[[Category: Ferm domain]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 11:03:11 2009''