5lup: Difference between revisions

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 ==Structures of DHBN domain of human BLM helicase==
-<StructureSection load='5lup' size='340' side='right' caption='[[5lup]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
+<StructureSection load='5lup' size='340' side='right'caption='[[5lup]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5lup]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LUP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LUP FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5lup]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LUP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LUP FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.032&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lup OCA], [http://pdbe.org/5lup PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lup RCSB], [http://www.ebi.ac.uk/pdbsum/5lup PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lup ProSAT]</span></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lup OCA], [https://pdbe.org/5lup PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lup RCSB], [https://www.ebi.ac.uk/pdbsum/5lup PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lup ProSAT]</span></td></tr>
 </table>
+== Disease ==
+[https://www.uniprot.org/uniprot/BLM_HUMAN BLM_HUMAN] Bloom syndrome. The disease is caused by mutations affecting the gene represented in this entry.
+== Function ==
+[https://www.uniprot.org/uniprot/BLM_HUMAN BLM_HUMAN] Participates in DNA replication and repair. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction. Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA. Negatively regulates sister chromatid exchange (SCE).<ref>PMID:9388193</ref> <ref>PMID:12019152</ref> <ref>PMID:21325134</ref> <ref>PMID:23509288</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 16: / Line 21: @@
 </div>
 <div class="pdbe-citations 5lup" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Helicase 3D structures|Helicase 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Ai, X]]
+[[Category: Homo sapiens]]
-[[Category: Chen, W F]]
+[[Category: Large Structures]]
-[[Category: Fan, S H]]
+[[Category: Ai X]]
-[[Category: Liu, N N]]
+[[Category: Chen W-F]]
-[[Category: Rety, S]]
+[[Category: Fan S-H]]
-[[Category: Shi, J]]
+[[Category: Liu N-N]]
-[[Category: Xi, X G]]
+[[Category: Rety S]]
-[[Category: Zhang, B]]
+[[Category: Shi J]]
-[[Category: Helicase dimerization alpha-helix motif]]
+[[Category: Xi X-G]]
-[[Category: Structural protein]]
+[[Category: Zhang B]]