5lqc: Difference between revisions

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 ==Crystal Structure of COMT in complex with N-[(E)-3-[(2R,3S,4R,5R)-3,4-dihydroxy-5-[6-(methylamino)purin-9-yl]oxolan-2-yl]prop-2-enyl]-5-(4-fluorophenyl)-2,3-dihydroxybenzamide==
-<StructureSection load='5lqc' size='340' side='right' caption='[[5lqc]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
+<StructureSection load='5lqc' size='340' side='right'caption='[[5lqc]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5lqc]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LQC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LQC FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5lqc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LQC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LQC FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=542:N-[(E)-3-[(2R,3S,4R,5R)-3,4-DIHYDROXY-5-(6-METHYLAMINOPURIN-9-YL)OXOLAN-2-YL]PROP-2-ENYL]-5-(4-FLUOROPHENYL)-2,3-DIHYDROXY-BENZAMIDE'>542</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.903&#8491;</td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Catechol_O-methyltransferase Catechol O-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.6 2.1.1.6] </span></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=542:N-[(E)-3-[(2R,3S,4R,5R)-3,4-DIHYDROXY-5-(6-METHYLAMINOPURIN-9-YL)OXOLAN-2-YL]PROP-2-ENYL]-5-(4-FLUOROPHENYL)-2,3-DIHYDROXY-BENZAMIDE'>542</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lqc OCA], [http://pdbe.org/5lqc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lqc RCSB], [http://www.ebi.ac.uk/pdbsum/5lqc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lqc ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lqc OCA], [https://pdbe.org/5lqc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lqc RCSB], [https://www.ebi.ac.uk/pdbsum/5lqc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lqc ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/COMT_RAT COMT_RAT]] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
+[https://www.uniprot.org/uniprot/COMT_RAT COMT_RAT] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
+==See Also==
+*[[Catechol O-methyltransferase 3D structures|Catechol O-methyltransferase 3D structures]]
 __TOC__
 </StructureSection>
-[[Category: Catechol O-methyltransferase]]
+[[Category: Large Structures]]
-[[Category: Ehler, A]]
+[[Category: Rattus norvegicus]]
-[[Category: Ellermann, M]]
+[[Category: Ehler A]]
-[[Category: Lerner, C]]
+[[Category: Ellermann M]]
-[[Category: Rudolph, M G]]
+[[Category: Lerner C]]
-[[Category: Methyltransferase]]
+[[Category: Rudolph MG]]
-[[Category: Neurotransmitter degradation]]
-[[Category: Transferase]]