5ll9: Difference between revisions

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-'''Unreleased structure'''
-The entry 5ll9 is ON HOLD  until Paper Publication
+==Crystal structure of human carbonic anhydrase isozyme XII with 4-(1H-benzimidazol-1-ylacetyl)-2-chlorobenzenesulfonamide==
+<StructureSection load='5ll9' size='340' side='right'caption='[[5ll9]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5ll9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LL9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LL9 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6YQ:4-[2-(benzimidazol-1-yl)ethanoyl]-2-chloranyl-benzenesulfonamide'>6YQ</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ll9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ll9 OCA], [https://pdbe.org/5ll9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ll9 RCSB], [https://www.ebi.ac.uk/pdbsum/5ll9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ll9 ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/CAH12_HUMAN CAH12_HUMAN] Defects in CA12 are the cause of hyperchlorhidrosis isolated (HCHLH) [MIM:[https://omim.org/entry/143860 143860]. HCHLH is a disorder characterized by excessive sweating and increased sweat chloride levels. Affected individuals suffer from episodes of hyponatremic dehydration and report increased amounts of visible salt precipitates in sweat.<ref>PMID:21035102</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/CAH12_HUMAN CAH12_HUMAN] Reversible hydration of carbon dioxide.
-Authors: Smirnov, A., Manakova, E., Grazulis, S.
+==See Also==
+*[[Carbonic anhydrase 3D structures|Carbonic anhydrase 3D structures]]
-Description: Crystal structure of human carbonic anhydrase isozyme XII with 4-(1H-benzimidazol-1-ylacetyl)-2-chlorobenzenesulfonamide
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
-[[Category: Manakova, E]]
+__TOC__
-[[Category: Grazulis, S]]
+</StructureSection>
-[[Category: Smirnov, A]]
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Grazulis S]]
+[[Category: Manakova E]]
+[[Category: Smirnov A]]