2y9j: Difference between revisions

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-[[Image:2y9j.png|left|200px]]
-{{STRUCTURE_2y9j|  PDB=2y9j  |  SCENE=  }}
+==THREE-DIMENSIONAL MODEL OF SALMONELLA'S NEEDLE COMPLEX AT SUBNANOMETER RESOLUTION==
+<SX load='2y9j' size='340' side='right' viewer='molstar' caption='[[2y9j]], [[Resolution|resolution]] 6.40&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2y9j]] is a 48 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y9J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y9J FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6.4&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y9j OCA], [https://pdbe.org/2y9j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y9j RCSB], [https://www.ebi.ac.uk/pdbsum/2y9j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y9j ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PRGH_SALTY PRGH_SALTY] Required for invasion of epithelial cells.
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Type III secretion systems (T3SSs) are essential virulence factors used by many Gram-negative bacteria to inject proteins that make eukaryotic host cells accessible to invasion. The T3SS core structure, the needle complex (NC), is a ~3.5 megadalton-sized, oligomeric, membrane-embedded complex. Analyzing cryo-electron microscopy images of top views of NCs or NC substructures from Salmonella typhimurium revealed a 24-fold symmetry for the inner rings and a 15-fold symmetry for the outer rings, giving an overall C3 symmetry. Local refinement and averaging showed the organization of the central core and allowed us to reconstruct a subnanometer composite structure of the NC, which together with confident docking of atomic structures reveal insights into its overall organization and structural requirements during assembly.
-===THREE-DIMENSIONAL MODEL OF SALMONELLA'S NEEDLE COMPLEX AT SUBNANOMETER RESOLUTION===
+Three-dimensional model of Salmonella's needle complex at subnanometer resolution.,Schraidt O, Marlovits TC Science. 2011 Mar 4;331(6021):1192-5. PMID:21385715<ref>PMID:21385715</ref>
-{{ABSTRACT_PUBMED_21385715}}
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-==About this Structure==
+<div class="pdbe-citations 2y9j" style="background-color:#fffaf0;"></div>
-[[2y9j]] is a 48 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y9J OCA].
+== References ==
+<references/>
-==Reference==
+__TOC__
-<ref group="xtra">PMID:021385715</ref><references group="xtra"/>
+</SX>
-[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]
+[[Category: Large Structures]]
-[[Category: Marlovits, T C.]]
+[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
-[[Category: Schraidt, O.]]
+[[Category: Marlovits TC]]
-[[Category: C24-fold]]
+[[Category: Schraidt O]]
-[[Category: Inner membrane ring]]
-[[Category: Ir1]]
-[[Category: Protein transport]]
-[[Category: Type iii secretion]]