7rrl: Difference between revisions

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'''Unreleased structure'''


The entry 7rrl is ON HOLD
==Alternate Crystal Form of Human Malate Dehydrogenase I==
<StructureSection load='7rrl' size='340' side='right'caption='[[7rrl]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7rrl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RRL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RRL FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rrl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rrl OCA], [https://pdbe.org/7rrl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rrl RCSB], [https://www.ebi.ac.uk/pdbsum/7rrl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rrl ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/MDHC_HUMAN MDHC_HUMAN] The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/MDHC_HUMAN MDHC_HUMAN] Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH (PubMed:3052244). Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation (PubMed:31538237).<ref>PMID:3052244</ref> <ref>PMID:31538237</ref>


Authors: McCue, W., Finzel, B.C.
==See Also==
 
*[[Malate Dehydrogenase 3D structures|Malate Dehydrogenase 3D structures]]
Description: Alternate Crystal Form of Human Malate Dehydrogenase I
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Mccue, W]]
__TOC__
[[Category: Finzel, B.C]]
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Finzel BC]]
[[Category: McCue W]]

Latest revision as of 19:36, 18 October 2023

Alternate Crystal Form of Human Malate Dehydrogenase IAlternate Crystal Form of Human Malate Dehydrogenase I

Structural highlights

7rrl is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.05Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

MDHC_HUMAN The disease is caused by variants affecting the gene represented in this entry.

Function

MDHC_HUMAN Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH (PubMed:3052244). Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation (PubMed:31538237).[1] [2]

See Also

References

  1. ↑ Friedrich CA, Ferrell RE, Siciliano MJ, Kitto GB. Biochemical and genetic identity of alpha-keto acid reductase and cytoplasmic malate dehydrogenase from human erythrocytes. Ann Hum Genet. 1988 Jan;52(1):25-37. doi: 10.1111/j.1469-1809.1988.tb01075.x. PMID:3052244 doi:http://dx.doi.org/10.1111/j.1469-1809.1988.tb01075.x
  2. ↑ Broeks MH, Shamseldin HE, Alhashem A, Hashem M, Abdulwahab F, Alshedi T, Alobaid I, Zwartkruis F, Westland D, Fuchs S, Verhoeven-Duif NM, Jans JJM, Alkuraya FS. MDH1 deficiency is a metabolic disorder of the malate-aspartate shuttle associated with early onset severe encephalopathy. Hum Genet. 2019 Dec;138(11-12):1247-1257. doi: 10.1007/s00439-019-02063-z. Epub, 2019 Sep 19. PMID:31538237 doi:http://dx.doi.org/10.1007/s00439-019-02063-z

7rrl, resolution 2.05Å

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