7riv: Difference between revisions
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<StructureSection load='7riv' size='340' side='right'caption='[[7riv]], [[Resolution|resolution]] 2.20Å' scene=''> | <StructureSection load='7riv' size='340' side='right'caption='[[7riv]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[7riv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[7riv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RIV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RIV FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=P06:DABRAFENIB'>P06</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7riv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7riv OCA], [https://pdbe.org/7riv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7riv RCSB], [https://www.ebi.ac.uk/pdbsum/7riv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7riv ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7riv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7riv OCA], [https://pdbe.org/7riv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7riv RCSB], [https://www.ebi.ac.uk/pdbsum/7riv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7riv ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/NR1I2_HUMAN NR1I2_HUMAN] Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes.<ref>PMID:9727070</ref> <ref>PMID:11668216</ref> <ref>PMID:11297522</ref> <ref>PMID:19297428</ref> <ref>PMID:12578355</ref> <ref>PMID:18768384</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 7riv" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 7riv" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Pregnane X receptor 3D structures|Pregnane X receptor 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Ward | [[Category: Ward P]] | ||
[[Category: Williams | [[Category: Williams SP]] | ||
[[Category: Wisely | [[Category: Wisely GB]] | ||